Results 71 to 80 of about 4,659,967 (205)

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner [PDF]

, 2008
The calcium/calmodulin-dependent kinase that phosphorylates and inactivates eukaryotic elongation factor 2 (eEF2 kinase; eEF2K) is subject to multisite phosphorylation, which regulates its activity.
Proud, C., Christopher G Proud, Proud, Christopher G., Smith, Ewan M., Smith, E., Ewan M Smith   +5 more
core   +1 more source

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway

BMC Complementary Medicine and Therapies, 2022
Background Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure.
Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu, Wenzhe Ma   +8 more
doaj   +1 more source

Mitotic Reorganization of the Intermediate Filament Protein Nestin Involves Phosphorylation by cdc2 Kinase [PDF]

Journal of Biological Chemistry, 2001
The intermediate filament protein nestin is expressed during early stages of development in the central nervous system and in muscle tissues. Nestin expression is associated with morphologically dynamic cells, such as dividing and migrating cells. However, little is known about regulation of nestin during these cellular processes. We have characterized
Sahlgren, C.M., Mikhailov, A., Hellman, J., Chou, Y.-H., Lendahl, U., Goldman, R.D., Eriksson, J.E.   +6 more
openaire   +2 more sources

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1209-1225, October 2026.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

Unphosphorylated Cdc2 associates with Chk1 kinase.

, 2015
(A) Cyclin B (Cdc13) was immunoprecipitated from untreated and CPT-treated (40μM CPT, 4h) cdc13-HA cells and the precipitated protein was detected with the anti-Cdc2 antibody. Wild type (cdc13+) cells were included as a negative control.
Victoria Hilditch (763611), Thomas Caspari (155113)   +1 more
core   +1 more source

CLK2 blockade modulates alternative splicing compromising MYC‐driven breast tumors

EMBO Molecular Medicine, 2018
MYC oncogene overexpression/amplification is common in multiple human cancers, in which it regulates proliferation, apoptosis and cell metabolism, among other processes, and its expression associates with poor prognosis.
Fernando Salvador, Roger R Gomis
doaj   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Human retinoblastoma protein (Rb) is phosphorylated by cdc2 kinase and MAP kinase in Xenopus maturing oocytes [PDF]

FEBS Letters, 1998
Xenopus oocyte meiotic maturation combines features of G0/G1 and G2/M transitions of the cell cycle. To study the in ovo Rb kinase activity, we have microinjected human Rb into oocytes. Microinjected human Rb localizes into the nucleus, is hypophosphorylated in prophase oocytes, becomes hyperphosphorylated during meiotic maturation and is ...
Taieb, Frederic, Karaiskou, A., Rime, Hélène, Jessus, Catherine   +3 more
openaire   +4 more sources

Expression of chicken lamin B2 in Escherichia coli : characterization of its structure, assembly, and molecular interactions [PDF]

, 1991
Chicken lamin B2, a nuclear member of the intermediate-type filament (IF) protein family, was expressed as a full-length protein in Escherichia coli.
Aebi, U., Peter, M., Lustig, A., E Heitlinger, M Häner, M Peter, Häner, M., Nigg, E. A., U Aebi, Heitlinger, E., A Lustig, E A Nigg, Heitlinger E, Häner M, Peter M, Aebi U, Lustig A, Nigg EA   +17 more
core   +1 more source