Results 51 to 60 of about 4,659,967 (205)

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, EarlyView.
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R. Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau [PDF]

Journal of Biological Chemistry, 2000
Neuronal Cdc2-like protein kinase (NCLK), a approximately 58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901). The biochemical nature of NCLK-microtubule association is not known.
K, Sobue, A, Agarwal-Mawal, W, Li, W, Sun, Y, Miura, H K, Paudel   +5 more
openaire   +2 more sources

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma Protein [PDF]

Journal of Biological Chemistry, 1997
The tumor suppressor retinoblastoma protein (RB) plays a central role in cellular growth regulation, differentiation, and apoptosis. Phosphorylation of RB results in a consequent loss of its ability to inhibit cell cycle progression. However, how RB phosphorylation might be regulated in apoptotic or postmitotic cells, such as neurons, remains unclear ...
Lee, KY, Helbing, CC, Choi, KS, Johnston, RN, Wang, JH   +4 more
openaire   +3 more sources

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Nadal-Ginard, B., Leonhardt, H., Leonhardt, Heinrich, Nadal-Ginard, Bernardo   +4 more
core   +1 more source

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro.

PLoS ONE, 2009
BackgroundMammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
doaj   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, Volume 143, Issue 41, November 5, 2026.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Phosphorylation of numatrin and other nuclear proteins by cdc2 containing CTD kinase cdc2/p58

Journal of Biological Chemistry, 1991
Numatrin is a nuclear matrix phosphoprotein whose synthesis and abundance were shown to be regulated during the cell cycle in mitogen-stimulated lymphocytes (Feuerstein, N., and Mond, J. (1987) J. Biol. Chem. 262, 11389-11397). We examined the effect of (a) CTD-kinase, which contains the cdc2 catalytic component (p34) in a complex with a p58 subunit ...
openaire   +2 more sources

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source