Results 21 to 30 of about 3,589,787 (212)

Synergistic Effect of MC-LR and C-Terminal Truncated HBx on HepG2 Cells and Their Effects on PP2A Mediated Downstream Target of MAPK Signaling Pathway

Frontiers in Genetics, 2020
C-terminally truncated hepatitis B virus (HBV) X (ctHBx) infection and exposure to microcystins-LR (MC-LR) can lead to human hepatitis and liver cancer, but the mechanism associated with their synergistically effects not been fully elucidated. The ctHBx (
Chanchan Xiao, Fanbiao Mei, Guanhua Ren, Long Long, Maojian Chen, Xiang Fang, Jilin Li, Kezhi Li, Yanping Tang, Tianren Huang, Wei Deng   +10 more
doaj   +1 more source

Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs

Marine Drugs, 2010
For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins.
Alicia Marquardt, Samuel Abernathy, Jose R. Escalona, Stephen A. Stricker   +3 more
doaj   +1 more source

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]

, 1998
Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D., Flaggs, Gail, Martinho, Rui G., Carr, Antony M., DeMaggio, Anthony J, Bentley, Nicola J., Hoekstra, Merl F.   +6 more
core   +4 more sources

Western blot analysis of Src kinase assays using peptide substrates ligated to a carrier protein

BioTechniques, 2004
We have applied intein-mediated peptide ligation (IPL) to the use of peptide substrates for kinase assays and subsequent Western blot analysis. IPL allows for the efficient ligation of a synthetic peptide with an N-terminal cysteine residue to an intein ...
Jie Xu, Luo Sun, Inca Ghosh, Ming-Qun Xu
doaj   +1 more source

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 [PDF]

Oncogene, 1999
Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly inhibit the ...
Q, Zhan, M J, Antinore, X W, Wang, F, Carrier, M L, Smith, C C, Harris, A J, Fornace   +6 more
openaire   +2 more sources

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Prince, J. A., Blennow, Kaj,, Zetterberg, H, Hampel, Harald, Zetterberg, H., Buerger, Katharina, Zetterberg, Henrik,, Wahlund, LO, Buerger, K., Hampel, H, Blennow, K, Wahlund, Lars-Olof, Minthon, L, Blennow, K., Hampel, H., Prince, Jonathan A., Minthon, L., Buerger, K, Johansson, A., Minthon, Lennart, Johansson, Annica,, Prince, JA, Minthon, Lennart,, Johansson, A   +23 more
core   +1 more source

Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation

Tumor Biology, 2017
Fibroblast growth factor 8b and androgen play important roles in cell proliferation of prostate cancer. We investigated the effects of fibroblast growth factor 8b and androgen on the proliferation of prostate cell lines and the corresponding ...
Wen-jun Xiao, Gui-ming Zhang, Ding-wei Ye   +2 more
doaj   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source

Regulation of Chk1

Cell Division, 2009
Chk1 is a serine/threonine protein kinase that is the effector of the G2 DNA damage checkpoint. Chk1 homologs have a highly conserved N-terminal kinase domain, and a less conserved C-terminal regulatory domain of ~200 residues.
Calonge Teresa M, Tapia-Alveal Claudia, O'Connell Matthew J   +2 more
doaj   +1 more source

Zinc regulates meiotic resumption in porcine oocytes via a protein kinase C-related pathway. [PDF]

PLoS ONE, 2014
Zinc is an extremely important trace element that plays important roles in several biological processes. However, the function of zinc in meiotic division of porcine oocytes is unknown.
Ming-Hui Zhao, Jung-Woo Kwon, Shuang Liang, Seon-Hyang Kim, Ying-Hua Li, Jeong-Su Oh, Nam-Hyung Kim, Xiang-Shun Cui   +7 more
doaj   +1 more source