Results 21 to 30 of about 4,659,967 (205)

A family of human cdc2‐related protein kinases. [PDF]

The EMBO Journal, 1992
The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2.
M, Meyerson, G H, Enders, C L, Wu, L K, Su, C, Gorka, C, Nelson, E, Harlow, L H, Tsai   +7 more
openaire   +2 more sources

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. [PDF]

Proceedings of the National Academy of Sciences, 1992
Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp. Quant. Biol. 56, 177-186 and Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C.
M R, Hellmich, H C, Pant, E, Wada, J F, Battey   +3 more
openaire   +2 more sources

The design of peptide-based substrates for the cdc2 protein kinase [PDF]

Biochemical Journal, 1995
The substrate sequence specificity of the cdc2 protein kinase from Pisaster ochraceus has been evaluated. The peptide, Ac-Ser-Pro-Gly-Arg-Arg-Arg-Arg-Lys-amide, serves as an efficient cdc2 kinase substrate with a Km of 1.50 +/- 0.04 microM and a Vmax. of 12.00 +/- 0.18 mumol/min per mg.
J, Srinivasan, M, Koszelak, M, Mendelow, Y G, Kwon, D S, Lawrence   +4 more
openaire   +2 more sources

Learning Induces a CDC2-Related Protein Kinase, KKIAMRE [PDF]

The Journal of Neuroscience, 1999
To elucidate molecular mechanisms in learning and memory, we analyzed expression of mRNAs in brains of rabbits undergoing eyeblink conditioning. Infusion of the transcription inhibitor actinomycin D into the cerebellar interpositus nucleus reversibly blocked learning but not performance of the conditioned response.
H, Gomi, W, Sun, C E, Finch, S, Itohara, K, Yoshimi, R F, Thompson   +5 more
openaire   +2 more sources

The Protein-tyrosine Kinase Lck Associates with and Is Phosphorylated by Cdc2 [PDF]

Journal of Biological Chemistry, 1996
The protein-tyrosine kinase Lck is essential for signaling through the T-cell antigen receptor. Treatment of T-cells with a variety of extracellular stimuli increases the phosphorylation of Lck on serine residues. This results in shifts in the apparent molecular weight of Lck to forms that exhibit reduced electrophoretic mobility on SDS-polyacrylamide ...
N I, Pathan, R L, Geahlen, M L, Harrison
openaire   +2 more sources

The Retinoblastoma Protein Physically Associates with the Human cdc2 Kinase [PDF]

Molecular and Cellular Biology, 1992
The protein product (pRB) of the retinoblastoma susceptibility gene functions as a negative regulator of cell proliferation, and its activity appears to be modulated by phosphorylation. Using a new panel of anti-human pRB monoclonal antibodies, we have investigated the biochemical properties of this protein. These antibodies have allowed us to detect a
Q J, Hu, J A, Lees, K J, Buchkovich, E, Harlow   +3 more
openaire   +2 more sources

Western blot analysis of Src kinase assays using peptide substrates ligated to a carrier protein

BioTechniques, 2004
We have applied intein-mediated peptide ligation (IPL) to the use of peptide substrates for kinase assays and subsequent Western blot analysis. IPL allows for the efficient ligation of a synthetic peptide with an N-terminal cysteine residue to an intein ...
Jie Xu, Luo Sun, Inca Ghosh, Ming-Qun Xu
doaj   +1 more source

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 [PDF]

Oncogene, 1999
Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly inhibit the ...
Q, Zhan, M J, Antinore, X W, Wang, F, Carrier, M L, Smith, C C, Harris, A J, Fornace   +6 more
openaire   +2 more sources

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Prince, J. A., Blennow, Kaj,, Zetterberg, H, Hampel, Harald, Zetterberg, H., Buerger, Katharina, Zetterberg, Henrik,, Wahlund, LO, Buerger, K., Hampel, H, Blennow, K, Wahlund, Lars-Olof, Minthon, L, Blennow, K., Hampel, H., Prince, Jonathan A., Minthon, L., Buerger, K, Johansson, A., Minthon, Lennart, Johansson, Annica,, Prince, JA, Minthon, Lennart,, Johansson, A, Lund University.   +24 more
core   +1 more source

Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation

Tumor Biology, 2017
Fibroblast growth factor 8b and androgen play important roles in cell proliferation of prostate cancer. We investigated the effects of fibroblast growth factor 8b and androgen on the proliferation of prostate cell lines and the corresponding ...
Wen-jun Xiao, Gui-ming Zhang, Ding-wei Ye   +2 more
doaj   +1 more source