Results 331 to 340 of about 384,579 (349)

Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors

Molecular and Cellular Biochemistry, 2002
HTLV-1 is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), where viral replication and transformation are largely dependent upon modification of regulatory and host cell cycle proteins.
Lai, Wang, Longwen, Deng, Kaili, Wu, Cynthia, de la Fuente, Dai, Wang, Kylene, Kehn, Anil, Maddukuri, Shanese, Baylor, Francisco, Santiago, Emmanuel, Agbottah, Sylviane, Trigon, Michel, Morange, Renaud, Mahieux, Fatah, Kashanchi   +13 more
openaire   +2 more sources

Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1

Biochemical and Biophysical Research Communications, 2008
DNA methyltransferase 1 (Dnmt1) is an enzyme that recognizes and methylates hemimethylated CpG after DNA replication to maintain methylation patterns. Although the N-terminal region of Dnmt1 is known to interact with various proteins, such as methyl-CpG-binding protein 2 (MeCP2), the associations of protein kinases with this region have not been ...
Isamu, Kameshita, Mari, Sekiguchi, Daisuke, Hamasaki, Yasunori, Sugiyama, Naoya, Hatano, Isao, Suetake, Shoji, Tajima, Noriyuki, Sueyoshi   +7 more
openaire   +2 more sources

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

Molecular Cancer Therapeutics, 2004
Phenethyl isothiocyanate (PEITC), a constituent of many cruciferous vegetables, offers significant protection against cancer in animals induced by a variety of carcinogens.
D. Xiao, Candace S. Johnson, D. Trump, Shivendra V. Singh   +3 more
semanticscholar   +1 more source

Reovirus Oncolysis- Role of cyclin-dependent kinase inhibitor 1

Cancer Cell & Microenvironment, 2015
New therapeutic interventions are essential for improved cancer management. Over the past decade, reovirus, a naturally-occurring oncolytic double-stranded RNA virus harboring an intrinsic preference to destroy mutant KRAS driven tumors, has shown novel promissory potential.
openaire   +1 more source

Regulation of G₁ cyclin‐dependent kinases in liver regeneration

Journal of Gastroenterology and Hepatology, 1998
The liver serves as a suitable model for studying tissue regeneration. Although various growth factors have been implicated in the promotion of this process, their precise role in liver regeneration remains to be elucidated. Whatever the extracellular signals may be, they all converge on cell cycle regulators in the nucleus, where the sequential ...
Masafumi, Menjo, Kyoji, Ikeda, Makoto, Nakanishi   +2 more
openaire   +3 more sources

Che-1 enhances cyclin-dependent kinase 5 expression and interacts with the active kinase-complex

NeuroReport, 2008
Che-1 is a nuclear protein involved in the regulation of gene transcription and cell proliferation. It has also been shown to localize to the cytoplasm of postmitotic neuronal cells, where it is able to interact with the microtubule-associated protein tau.
Buontempo S, Barbato C, Bruno T, Corbi N, Ciotti MT, Floridi A, Fanciulli M, Passananti C   +7 more
openaire   +4 more sources

Regulation of AMP‐Activated Protein Kinase by Cyclin‐Dependent Kinase 1 in Mitosis

The FASEB Journal, 2016
In this study, we found that phosphorylation of both of the alpha subunits of AMP‐Activated Protein Kinase (AMPKα) are intensified in mitotically arrested cells. Further study showed that this was not due to phosphorylation at Thr172.
Seth D Stauffer, Xingcheng Chen, Yuanhong Chen, Jixin Dong   +3 more
openaire   +1 more source

Cyclin-Dependent Kinase 1: Expression pattern and therapeutic implications

2022
Sofi, Shazia, Mir, Manzoor Ahmad
openaire   +1 more source

Wee1 and Cdc25 control morphogenesis, virulence and multistress tolerance of Beauveria bassiana by balancing cell cycle-required cyclin-dependent kinase 1 activity.

Environmental Microbiology, 2015
Lei Qiu, Juan-juan Wang, S. Ying, M. Feng   +3 more
semanticscholar   +1 more source

Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026.

Cancer research, 2004
Cyclin-dependent kinases (Cdks) have been attractive targets for the development of anticancer therapeutic agents. In an effort to generate a new class of anti-Cdk inhibitors, we synthesized aryl aminopyrimidines and examined the effect of these compounds in both in vitro kinase assays and cultured cells.
Yeon-Sun, Seong, Changhee, Min, Luowei, Li, Jae Young, Yang, Soo-Yeon, Kim, Xiaodong, Cao, Keetae, Kim, Stuart H, Yuspa, Hyun-Ho, Chung, Kyung S, Lee   +9 more
openaire   +1 more source