Results 331 to 340 of about 805,965 (369)

Regulation of Osteoblast to Osteocyte Differentiation by Cyclin‐Dependent Kinase‐1

Advanced Biology, 2023
AbstractOsteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance.
Tomoyuki Tanaka, Yuri Miyakoshi, Yutaka Kobayashi, Sun Xiaolong, Yu Daiyang, Hiroki Ochi, Shingo Sato, Tsuyoshi Kato, Toshitaka Yoshii, Atsushi Okawa, Philipp Kaldis, Hiroyuki Inose   +11 more
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Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress

Current Medicinal Chemistry, 2011
Cyclin dependent kinases (CDKs) are a family of proteins involved in the regulation of cell cycle progression and attractive targets in oncology. The regulation of CDKs activities is achieved by their association with cyclin partners and kinases, phosphatases and specific inhibitors.
Hao Fang, L. Su, Lei Zhang, Wenfang Xu, Ning Liu, Qiang Wang   +5 more
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Molecular models of cyclin-dependent kinase 1 complexed with inhibitors

Biochemical and Biophysical Research Communications, 2004
Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). The structures of CDK2 complexed with roscovitine and deschoroflavopiridol have been reported, however no crystallographic structure is available for complexes of CDK1 with inhibitors.
Fernanda Canduri, Fernanda Canduri, Walter Filgueira de Azevedo, Walter Filgueira de Azevedo, Hugo Brandão Uchôa   +4 more
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Reovirus Oncolysis- Role of cyclin-dependent kinase inhibitor 1 [PDF]

Cancer Cell & Microenvironment, 2015
New therapeutic interventions are essential for improved cancer management. Over the past decade, reovirus, a naturally-occurring oncolytic double-stranded RNA virus harboring an intrinsic preference to destroy mutant KRAS driven tumors, has shown novel promissory potential.
Sanjay Goel, Titto Augustine, Radhashree Maitra, Madhukumar Venkatesh   +3 more
openaire   +1 more source

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

Journal of Medicinal Chemistry, 2008
Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key molecular features of Alzheimer's disease, production of amyloid-beta peptides (extracellular plaques) and hyper-phosphorylation of Tau (intracellular neurofibrillary tangles).
Oumata, Nassima, Bettayeb, Karima, Ferandin, Yoan, Demange, Luc, Lopez-Giral, Angela, Goddard, Marie-Lore?ne, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Flajolet, Marc, Greengard, Paul, Meijer, Laurent, Galons, Herve?   +11 more
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Pharmacological Cyclin-Dependent Kinase Inhibitors as HIV-1 Antiviral Therapeutics

Current HIV Research, 2003
Human immunodeficiency virus type 1 (HIV-1) can infect quiescent cells; however, viral production is restricted to actively proliferating cells. Recent evidence has indicated that HIV-1 viral proteins, Vpr and Tat, perturb the cell cycle to optimize HIV-1 replication. Vpr arrests the cell cycle at G2 by inactivating the cyclin B/cdk1 complex.
Kylene Kehn, Cynthia de la Fuente, Shanese Baylor, Longwen Deng, Fatah Kashanchi, Anne Pumfery, Anil Maddukuri   +6 more
openaire   +3 more sources

Quantitative structure-activity relationships of cyclin-dependent kinase 1 inhibitors

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2007
A new approach for quantitative structure-activity relationships based on MNA descriptors, fuzzy gradation method and self-consistent regression has been proposed. This approach has been realized in the computer program GUSAR (General Unrestricted Structure Activity Relationships). Our method has been validated on CDK1 inhibitors.
Dmitry Filimonov, Alexey V. Zakharov, Alexey Lagunin, Poroĭkov Vv   +3 more
openaire   +2 more sources

3D-QSAR CoMFA Study on Oxindole Derivatives as Cyclin Dependent Kinase 1 (CDK1) and Cyclin Dependent Kinase 2 (CDK2) Inhibitors

Medicinal Chemistry, 2007
Cyclin dependent kinases have emerged as important drug targets with a multitude of therapeutic potentials for their inhibitors. With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA study carried out on oxindole derivatives
Sanjeev Kumar Singh, Prasad V. Bharatam, Nigus Dessalew   +2 more
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Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors.

Molecular and cellular biochemistry, 2002
HTLV-1 is the etiologic agent for adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), where viral replication and transformation are largely dependent upon modification of regulatory and host cell cycle proteins.
Sylviane Trigon, Renaud Mahieux, Fatah Kashanchi, Anil Maddukuri, Francisco Santiago, Kaili Wu, Lai Wang, Cynthia de la Fuente, Emmanuel Agbottah, Kylene Kehn, Dai Wang, Shanese Baylor, Michel Morange, Longwen Deng   +13 more
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Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle

Current Opinion in Cell Biology, 2000
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in ...
Steven I. Reed, Susanna V. Ekholm
openaire   +3 more sources