Results 171 to 180 of about 543,132 (243)

Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2 [PDF]

, 2007
Ho Jung Kim, Eunjung Lee, Jihye Kim, Kwang‐Su Park, Haeyoung Lim, Chul‐Hoon Lee, Joong-Hoon Ahn, Youhoon Chong, Yoongho Lim   +8 more
openalex   +1 more source

Cyclin-Dependent Kinase 2/Cyclin E Complex Is Involved in p120 Catenin (p120ctn)–Dependent Cell Growth Control: A New Role for p120ctn in Cancer [PDF]

, 2007
Nicolas T. Chartier, Christiane Oddou, Michèle G. Lainé, Benjamin Ducarouge, Christiane Marie, Marc R. Block, Muriel R. Jacquier‐Sarlin   +6 more
openalex   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2 [PDF]

, 2008
Zelda H. Cheung, Ke Gong, Nancy Y. Ip
openalex   +1 more source

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding [PDF]

, 2008
Graham S. Baldwin
openalex   +1 more source

Exploration of histone protein γ‐H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.
What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann, Sebastian Walter, Lena Hieggelke, Reinhard Buettner, Christiane Josephine Bruns, Peer Eysel, Lars Mortimer Schiffmann, Karl Knipper, Peter Mallmann, Alexander Quaas, Roland Ullrich   +14 more
wiley   +1 more source

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells [PDF]

, 2008
Wenwei Lin, Jing Wu, Hanqing Dong, David C. Bouck, Fu-Yue Zeng, Taosheng Chen   +5 more
openalex   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source