Cancer Communications, EarlyView.Abstract Background N‐acetyltransferase 10 (NAT10) was reported to be associated with the immune microenvironment in several cancers. However, it is not known in pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucidate the roles and mechanisms of NAT10 in tumor malignancy and the tumor microenvironment (TME) in PDAC.
Enhong Chen +11 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu +16 more
wiley +1 more source
Phenoxodiol, a Novel Isoflavone, Induces G1 Arrest by Specific Loss in Cyclin-Dependent Kinase 2 Activity by p53-Independent Induction of p21WAF1/CIP1 [PDF]
, 2005 Martin F. Aguero +3 more
openalex +1 more source
Novel Role for Cyclin-dependent Kinase 2 in Neuregulin-induced Acetylcholine Receptor ϵ Subunit Expression in Differentiated Myotubes [PDF]
, 2005 Gang Lü +2 more
openalex +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
Editorial Expression of Concern: Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. [PDF]
Br J CancerJohnson N +6 more
europepmc +1 more source
Identification of High-Affinity Inhibitors of Cyclin-Dependent Kinase 2 Towards Anticancer Therapy. [PDF]
Molecules, 2019 Mohammad T +6 more
europepmc +1 more source
Topochemical models for prediction of cyclin-dependent kinase 2 inhibitory activity of indole-2-ones [PDF]
, 2005 Harish Dureja, Anil Kumar Madan
openalex +1 more source
Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential
Chemistry &Biodiversity, EarlyView.Leaves of Eugenia brasiliensis were dried, crushed and macerated with polarity increment. The antiporliferative and anti‐migratory potential and the cell cycle were evaluated. 28 compounds were tentatively identified by mass sceptrometry. ABSTRACT This work evaluated the antiproliferative potential of Eugenia brasiliensis leaf extracts against the HeLa
Giovana G. F. V. de Oliveira +9 more
wiley +1 more source
Clinicopathological Significance of Cyclin-Dependent Kinase 2 (CDK2) in Ductal Carcinoma In Situ and Early-Stage Invasive Breast Cancers. [PDF]
Int J Mol SciLashen A +7 more
europepmc +1 more source