Results 251 to 260 of about 338,209 (343)

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma--A novel therapeutic approach.

Journal of Hepatology, 2014
Sandra M. Ehrlich, J. Liebl, M. Ardelt, T. Lehr, E. D. De Toni, D. Mayr, L. Brandl, T. Kirchner, S. Zahler, A. Gerbes, A. Vollmar   +10 more
semanticscholar   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. [PDF]

Int J Mol Sci, 2020
Yashima H, Terasaki M, Sotokawauchi A, Matsui T, Mori Y, Saito T, Osaka N, Kushima H, Hiromura M, Ohara M, Fukui T, Yamagishi SI.   +11 more
europepmc   +1 more source

Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5.

Neuroscience, 2003
S. Norrholm, J. Bibb, J. Bibb, Eric J. Nestler, C. Ouimet, JaneR . Taylor, P. Greengard   +6 more
semanticscholar   +1 more source

Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4‐Mediated Ferroptosis

Small, EarlyView.
ABSTRACT Pancreatic cancer, one of the most malignant solid tumors with the poorest prognosis, is commonly treated with gemcitabine (GEM)‐based systemic chemotherapy. However, chemoresistance remains a significant therapeutic challenge. Ferroptosis, a novel form of programmed cell death, has demonstrated exceptional susceptibility in chemoresistant ...
Jiaqiang Ren, Shuai Wu, Tong Su, Hugang Li, Jiachun Ding, Fan Chen, Jiantao Mo, Jie Li, Zheng Wang, Liang Han, Zheng Wu   +10 more
wiley   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ. [PDF]

Biomolecules, 2020
Ahn S, Jang DM, Park SC, An S, Shin J, Han BW, Noh M.   +6 more
europepmc   +1 more source

The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae

Yeast, EarlyView.
ABSTRACT To maintain the integrity of the genome, cells have evolved a complex signalling system, termed the DNA damage response (DDR), which detects DNA damage and promotes DNA repair. To date, over 600 proteins have been identified that play an integral role in the DDR. RAD9, encoding a DDR mediator protein, was the prototypical DNA damage checkpoint
A. Kiely, F. O'Halloran, P. Young, N. F. Lowndes, M. Grenon, K. Finn   +5 more
wiley   +1 more source

Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress.

Molecular Endocrinology, 2007
T. Kino, T. Ichijo, N. Amin, S. Kesavapany, Yonghong Wang, Nancy Kim, Sandesh Rao, A. Player, Ya-Li Zheng, M. Garabedian, E. Kawasaki, H. Pant, G. Chrousos   +12 more
semanticscholar   +1 more source

Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes

Annals of Applied Biology, EarlyView.
This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy, Emad Ibrahim, Jan Ripl, Jiban K. Kundu   +3 more
wiley   +1 more source