Results 31 to 40 of about 338,209 (343)

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover.

Biological Psychiatry, 2019
BACKGROUND Synaptic protein dyshomeostasis and functional loss is an early invariant feature of Alzheimer's disease (AD), yet the unifying etiological pathway remains largely unknown.
Jiechao Zhou, H. Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yue Gao, Guimiao Chen, Kai Zhuang, Huizhong Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Haoyue Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, G. Bu, Huaxi Xu, Zengqiang Yuan, K. Herrup, Jie Zhang   +26 more
semanticscholar   +1 more source

Cyclin-Dependent Kinase 5 Is Required for Associative Learning [PDF]

The Journal of Neuroscience, 2002
Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress.
Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., Radulovic, J.   +4 more
openaire   +4 more sources

Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids

Neurobiology of Disease, 2023
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in ...
Marta Barrera-Conde, Emma Veza-Estévez, Maria Gomis-Gonzalez, Jordi Garcia-Quintana, Amira Trabsa, Laura Martínez-Sadurní, Mitona Pujades, Víctor Perez, Rafael de la Torre, Daniel Bergé, Patricia Robledo   +10 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

Journal of Neuroscience, 2005
Inflammation is a critical component of the pathogenesis of Alzheimer's disease (AD). Although not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a driving force that can modulate the neuropathology.
M. Kitazawa, S. Oddo, T. R. Yamasaki, K. Green, F. LaFerla   +4 more
semanticscholar   +1 more source

Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.

PLoS ONE, 2009
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli, Della Koovakkattu, Kanehiro Hayashi, Anne E Anderson, Craig M Powell, Christopher M Sinton, James A Bibb, Donald C Cooper   +7 more
doaj   +1 more source

A kinase of many talents: non-neuronal functions of CDK5 in development and disease [PDF]

Open Biology, 2020
The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established.
Samanta Sharma, Piotr Sicinski
doaj   +1 more source

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S., Jaiswal, H., Lindqvist, A., Müllers, E., Saurin, A.T.   +4 more
core   +4 more sources

The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons

Scientific Reports, 2018
Cyclin-dependent kinase 5 (CDK5) plays a pivotal role in neural development and neurodegeneration. CDK5 activity can be regulated by posttranslational modifications, including phosphorylation and S-nitrosylation.
Juhyung Lee, Yeon Uk Ko, Yuhyun Chung, N. Yun, Myungjin Kim, Kyungjin Kim, Y. Oh   +6 more
semanticscholar   +1 more source

SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana [PDF]

, 2006
Recessive mutations in the SIAMESE (SIM) gene of Arabidopsis thaliana result in multicellular trichomes harboring individual nuclei with a low ploidy level, a phenotype strikingly different from that of wild-type trichomes, which are single cells with a ...
Churchman, Michelle L, Brown, Matthew L, Kato, Naohiro, Kirik, Viktor, Hülskamp, Martin, Inzé, Dirk, De Veylder, Lieven, Walker, Jason D, Zheng, Zhengui, Oppenheimer, David G, Gwin, Taylor, Churchman, Jason, Larkin, John C   +12 more
core   +3 more sources