Cyclin C: The Story of a Non-Cycling Cyclin
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek +8 more
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Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]
, 2013 Peer reviewedPublisher ...
Martin, Samuel A.M. +3 more
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Regulation of NMDA receptors by cyclin-dependent kinase-5 [PDF]
Proceedings of the National Academy of Sciences, 2001 Members of the N -methyl- d -aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system.
B S, Li +8 more
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Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5 [PDF]
Biochemical Journal, 2004 Doublecortin (DCX) is a 40 kDa microtubule-associated protein required for normal neural migration and cortical layering during development. Mutations in the human DCX gene cause a disruption of cortical neuronal migration. Defects in cdk5 (cyclin-dependent kinase 5) also cause defects in neural migration and cortical layering.
Mark E, Graham +7 more
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Crosstalk between Cdk5 and GSK3β: Implications for Alzheimer's Disease
Frontiers in Molecular Neuroscience, 2009 GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration.
Olivia Engmann, Karl P Giese
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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
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Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review [PDF]
Pediatric Neurology, 2019 Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This unique disorder includes early infantile onset refractory epilepsy, hypotonia, developmental intellectual and motor disabilities, and cortical visual impairment.
Olson, HE +9 more
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The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer
CellsCyclin-dependent kinase 5 (Cdk5) is an atypical serine/threonine kinase distinct from classical cell cycle regulators. Its activity is highest in the nervous system and essential for development, but its functions in other tissues, particularly in cancer,
Yoshiaki V. Nishimura, Takeshi Kawauchi
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Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells
Translational Neuroscience, 2023 Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells.
Bao Li +11 more
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Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
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