Results 61 to 70 of about 338,209 (343)

Cyclin-Dependent Kinase 5 in Amyotrophic Lateral Sclerosis

Neurosignals, 2003
Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering ...
Minh Dang, Nguyen, Jean-Pierre, Julien
openaire   +2 more sources

Cyclin-dependent Kinase 5: Novel role of gene variants identified in ADHD

Scientific Reports, 2017
Cortical neuronal migration and formation of filamentous actin cytoskeleton, needed for development, normal cell growth and differentiation, are regulated by the cyclin-dependent kinase 5 (Cdk5).
Subhamita Maitra, Mahasweta Chatterjee, Swagata Sinha, Kanchan Mukhopadhyay   +3 more
doaj   +1 more source

Crosstalk between Cdk5 and GSK3β: Implications for Alzheimer's Disease

Frontiers in Molecular Neuroscience, 2009
GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration.
Olivia Engmann, Karl P Giese
doaj   +1 more source

Cyclin Dependent Kinase 5 in Endothelial Cell Migration [PDF]

, 2010
Cyclin dependent kinase 5 (Cdk5) is studied to take part in the migration neurons and development of brain. It is proven to participate also in the mediation of endothelial cell migration and angiogenesis.
Heiskanen, Suvi
core  

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]

, 2014
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura, Cayrol, Maria Florencia, Colombo, L., Cremaschi, Graciela Alicia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Martinel Lamas, Diego José, Medina, Vanina Araceli, Paulazo, Maria Alejandra, Sterle, Helena Andrea, Valli, Eduardo   +10 more
core   +1 more source

Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression

Translational Psychiatry, 2015
Stress activates the hypothalamic–pituitary–adrenal axis, which in turn increases circulating glucocorticoid concentrations and stimulates the glucocorticoid receptor (GR).
A. Papadopoulou, T. Siamatras, Raúl Delgado-Morales, N. Amin, V. Shukla, Ya-Li Zheng, Harish C. Pant, Osborne F. X. Almeida, Tomoshige Kino   +8 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]

, 2011
Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M, Iofik, Anna, Kõivomägi, Mardo, Lepiku, Martin, Loog, Mart, Morgan, David O, Rubin, Seth M, Valk, Ervin, Venta, Rainis   +8 more
core   +2 more sources

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Journal of Neuroscience, 2004
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid β-peptide (Aβ)1–42 on the induction of long-term potentiation (LTP) were investigated in the medial perforant path to dentate granule cell synapses in hippocampal ...
Qinwen Wang, D. Walsh, M. Rowan, D. Selkoe, R. Anwyl   +4 more
semanticscholar   +1 more source

Cyclin‐dependent kinase 5 regulates degranulation in human eosinophils [PDF]

Immunology, 2015
SummaryDegranulation from eosinophils in response to secretagogue stimulation is a regulated process that involves exocytosis of granule proteins through specific signalling pathways. One potential pathway is dependent on cyclin‐dependent kinase 5 (Cdk5) and its effector molecules, p35 and p39, which play a central role in neuronal cell exocytosis by ...
Solomon O, Odemuyiwa, Ramses, Ilarraza, Francis, Davoine, Michael R, Logan, Anooshirvan, Shayeganpour, Yingqi, Wu, Carina, Majaesic, Darryl J, Adamko, Redwan, Moqbel, Paige, Lacy   +9 more
openaire   +2 more sources