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Endothelial Foxp1 Regulates Neointimal Hyperplasia Via Matrix Metalloproteinase‐9/Cyclin Dependent Kinase Inhibitor 1B Signal Pathway [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The endothelium is essential for maintaining vascular physiological homeostasis and the endothelial injury leads to the neointimal hyperplasia because of the excessive proliferation of vascular smooth muscle cells.
Xiaoli Chen, Jianfei Xu, Wenzhen Bao, Hongda Li, Wenrun Wu, Jiwen Liu, Jingjiang Pi, Brian Tomlinson, Paul Chan, Chengchao Ruan, Qi Zhang, Lin Zhang, Huimin Fan, Edward Morrisey, Zhongmin Liu, Yuzhen Zhang, Li Lin, Jie Liu, Tao Zhuang   +18 more
doaj   +2 more sources

The cyclin dependent kinase inhibitor p21Cip1/Waf1 is a therapeutic target in high-risk neuroblastoma [PDF]

Frontiers in Oncology, 2022
Platinum-based chemotherapies such as cisplatin are used as first-line treatment for the paediatric tumour neuroblastoma. Although the majority of neuroblastoma tumours respond to therapy, there is a high fraction of high-risk neuroblastoma patients that
Agnes Luise Sorteberg, Vesa Halipi, Malin Wickström, Shahrzad Shirazi Fard   +3 more
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Cyclin-Dependent Kinase Inhibitor 2A/B Homozygous Deletion Prediction and Survival Analysis [PDF]

Brain Sciences, 2023
Cyclin-Dependent Kinase Inhibitor 2A/B (CDKN2A/B) homozygous deletion was a significant prognostic factor for gliomas and affected the treatment strategy.
Jing Yang, Lei Li, Tao Luo, Chengsong Nie, Rui Fan, Deqiang Li, Rui Yang, Changru Zhou, Qian Li, Xiaofei Hu, Wei Chen   +10 more
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The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice [PDF]

Scientific Reports, 2021
Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer   +6 more
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Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells

Pharmaceutical Biology, 2023
Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu   +4 more
doaj   +1 more source

Immunohistochemical Expression of p27^Kip1, p57^Kip2, Cyclin D1, Nestin, and Ki-67 in Ependymoma

Brain Sciences, 2022
p27 and p57 are tumor suppressors that are dysregulated in many cancers. We investigated the immunohistochemical expression of p27 and p57 in ependymoma, with a secondary emphasis on cyclin D1, nestin, and Ki-67.
Shahad Iqneibi, Jamil Nazzal, Basma Owda, Hala Sultan, Runa Amoudi, Justin Z. Amarin, Sura Al-Ghnimat, Mamoun Ahram, Maysa Al-Hussaini   +8 more
doaj   +1 more source

Exploring cell cycle-mediated regulations of glycolysis in budding yeast

Frontiers in Microbiology, 2023
Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang, Yanfei Zhang, Matteo Barberis, Matteo Barberis, Matteo Barberis   +4 more
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Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma

Kouqiang hemian waike zazhi, 2023
Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and ...
HOU Zeyu, TANG Jinru, LI Longjiang
doaj   +1 more source

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source

Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases

Pharmaceuticals, 2023
Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
doaj   +1 more source