Results 11 to 20 of about 215,802 (313)

Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]

Anais Brasileiros de Dermatologia, 2016
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira   +5 more
doaj   +1 more source

New Imadazopyrazines with CDK9 Inhibitory Activity as Anticancer and Antiviral: Synthesis, In Silico, and In Vitro Evaluation Approaches

Pharmaceuticals, 2023
This study describes the synthesis and biological activity of new imadazopyrazines as first-in-class CDK9 inhibitors. The inhibition of CDK9 is a well-established therapeutic target in cancer therapy.
Aisha A. Alsfouk, Hanan M. Alshibl, Najla A. Altwaijry, Ashwag Alanazi, Omkulthom AlKamaly, Ahlam Sultan, Bshra A. Alsfouk   +6 more
doaj   +1 more source

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]

, 2014
Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian, Musgrove, Elizabeth A., Sergio, C. Marcelo, Sutherland, Robert L.   +3 more
core   +2 more sources

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells [PDF]

, 2013
Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid ...
Alison M. McCaig, Alison M. Michie, Byrd, Christian Berthou, Emilie Durieu, Emilio Cosimo, Helen Wheadon, Hervé Galons, Karine Le Ster, Kitada, Laurent Meijer, Luke J.M. Carter-Brzezinski, Michael T. Leach, Nassima Oumata, Pepper   +14 more
core   +1 more source

Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

Acta Pharmaceutica Sinica B, 2022
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this ...
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung   +12 more
doaj   +1 more source

Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Laboratory Animal Research, 2018
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.
Bo Min Park, Jae-il Roh, Jaehoon Lee, Han-Woong Lee   +3 more
doaj   +1 more source

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

PLoS ONE, 2023
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in ...
Anna McGriff, William J Placzek
doaj   +1 more source

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency

Virus Research, 2023
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for ...
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall   +12 more
doaj   +1 more source

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Berberich, Nina, Fürst, Robert, Joore, Jos, Khandoga, Alexander G., Krombach, Fritz, Mayer, Bettina A., Sass, Gabriele, Schmerwitz, Ulrike K., Tiegs, Gisa, Totzke, Frank, Vollmar, Angelika M., Zahler, Stefan   +11 more
core   +1 more source

Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]

PLoS ONE, 2011
During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi, Masayuki Fukui, Bao Ting Zhu   +2 more
doaj   +1 more source