Results 261 to 270 of about 215,802 (313)
Some of the next articles are maybe not open access.
2-Aminoquinazoline inhibitors of cyclin-dependent kinases
Bioorganic & Medicinal Chemistry Letters, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Yadagiri, Bathini +8 more
openaire +2 more sources
Ras versus cyclin-dependent kinase inhibitors
Current Opinion in Genetics & Development, 1998In the past year, complex interactions between Ras and the cell cycle have been identified. In primary cells, activated Ras induces a cell-cycle arrest via the induction of cyclin-dependent kinase inhibitors (CDKIs). Oncogenic changes that cooperate with Ras act by neutralising CDKIs by various mechanisms.
openaire +2 more sources
Chemical inhibitors of cyclin-dependent kinases
Trends in Cell Biology, 1995The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
openaire +3 more sources
Inhibitors of cyclin-dependent kinase and cancer
Journal of Molecular Medicine, 1995Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
J R, Biggs, A S, Kraft
openaire +2 more sources
Synthetic Cyclin Dependent Kinase Inhibitors
1999The unsatisfactory results of current anti-cancer therapies require the active search for new drugs, new treatment strategies and a deeper understanding of the host-tumour relationship. From this point of view, the drugs with a capacity to substitute the functions of altered tumour suppressor genes are of prominent interest.
Marián Hajdúch +5 more
openaire +1 more source
Novel Potent Pharmacological Cyclin-Dependent Kinase Inhibitors
Future Medicinal Chemistry, 2009Progression of the cell cycle is controlled by various activating and inhibiting cellular factors. The subtle balance between these counteracting regulators in normal cells ensures proper cell cycle progression and facilitates cellular responses to a variety of stress stimuli.
Józefa, Węsierska-Gądek +2 more
openaire +2 more sources
Cyclin dependent kinase inhibitors.
Cancer surveys, 1997Progression through the eukaryotic cell cycle is regulated by the activities of a family of cyclin dependent kinases (CDKs). These kinases are negatively regulated by phosphorylation and by the action of cyclin kinase inhibitors (CKIs). In mammalian cells, two classes of CKIs have been identified, the INK4 class and the CIP/KIP class.
openaire +1 more source
Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs
Current Drug Targets, 2010Poor therapeutic outcomes and serious side effects, together with acquired resistance to multiple drugs, are common problems of current cancer therapies. Therefore, there is an urgent need for new cancer-targeted drugs, which has led (inter alia) to the development of molecules that can specifically inhibit cyclin-dependent kinases (CDKs).
Vladimír, Krystof, Stjepan, Uldrijan
openaire +2 more sources
Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors
2023Nathan H. Lents +1 more
openaire +1 more source
Cyclin Dependent Kinase (CDK) Inhibitors
1998Cyclin-dependent kinase inhibitors of saccharomyces cerevisiae and schizosaccharomyces pombe inhibitors of the Cip/Kip family the INK4 family of CDK inhibitors role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development roles of CDK inhibitors - lessons from knockout mice p21/p53, cellular growth control and ...
openaire +1 more source