Results 101 to 110 of about 33,889 (223)
Endocrine Connections, 2018 Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) system currently encompasses approved therapy with the mammalian target of rapamycin (mTOR) inhibitor everolimus and the multi-tyrosinkinase ...
E T Aristizabal Prada +1 more
doaj +1 more source
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases [PDF]
, 2013 The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3 ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family of E3 ubiquitin ligases in mammals.
Sun, Yi, Wei, Wenyi, Zhou, Weihua
core +1 more source
Cancer Innovation, Volume 5, Issue 2, April 2026.Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun +13 more
wiley +1 more source
Journal of Pharmacological Sciences, 2006 .: During CNS development, multipotent neural stem cells give rise first to various kinds of specified precursor cells, which proliferate extensively before terminally differentiating into either neurons or glial cells.
Ishizaki Yasuki
doaj +1 more source
Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]
, 2011 A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed.
I. C. Baianu
core +1 more source
Trithorax group proteins: switching genes on and keeping them active [PDF]
, 2011 Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G. +3 more
core +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Created in BioRender. Haralambie, O. (2025) https://BioRender.com/dh5ly89. ABSTRACT Digestive disorders such as inflammatory bowel disease (IBD) and colorectal cancer are among the most significant global health challenges, largely driven by chronic inflammation and oxidative stress.
Oana‐Roxana Haralambie, Sanda Andrei
wiley +1 more source
Chinese Journal of Lung Cancer, 2008 Background and objective S-phase kinase-associated protein 2 (Skp2) is one of the positive regulators of the cell cycle that promote Ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27.
Xiaohua HU +3 more
doaj
Quercetin elevates p27Kip1 and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 [PDF]
, 2003 Our previous work with primary bovine fibroblasts demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 and G2/M, in correlation with p53 activation.
Alan G. Casson +30 more
core +1 more source
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein [PDF]
, 1997 p21 inhibits cyclin-dependent kinase (CDK) activity and proliferating cell nuclear antigen (PCNA)-dependent DNA replication by binding to CDK/cyclin complexes and to PCNA through distinct domains.
Espling, E. +5 more
core +1 more source