Results 111 to 120 of about 76,308 (284)

Interplay between CKS2, N-cadherin, and PD-ECGF in Non-Schistosomal and Schistosomal-Associated Bladder Cancer: A Prospective Comparative Study in the Egyptian Population

Middle East Journal of Cancer, 2017
Background: The current study investigated the possible role of the cell cycle regulator, cyclin-dependent kinases regulatory subunit-2; the angiogenic factor, plateletderived endothelial cell growth factor; and the cell adhesive molecule, neural ...
Sanaa Shawky, Mona Salem, Hoda Abou Seif, Salah El Din El Salmy, Manal Sheta, Eman El-Abd   +5 more
doaj  

The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis

Biochemistry and Biophysics Reports, 2016
Osteoclasts are multinucleated cells with bone resorption activity that is crucial for bone remodeling. RANK‐RANKL (receptor activator of nuclear factor κB ligand) signaling has been shown as a main signal pathway for osteoclast differentiation. However,
Yosuke Akiba, Akiko Mizuta, Yoshito Kakihara, Juri Nakata, Jun Nihara, Isao Saito, Hiroshi Egusa, Makio Saeki   +7 more
doaj   +1 more source

Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes [PDF]

, 2013
We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation.
Abe, Hiroshi, De Bock, Pieter-Jan, Fujiki, Saburo, Gevaert, Kris, Iwase, Shohei, Kuchitsu, Miyako, Ono, Shoichiro, Sato, Ryuhei, Tawada, Toshinobu, Yamagishi, Yuka   +9 more
core   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY

Опухоли женской репродуктивной системы, 2018
Although metastatic breast cancer remains an incurable disease, significant achievements have been made in this area over the recent years, allowing to convert breast cancer into a chronically controlled disease characterized by a torpid course. Patients
E. V. Artamonova
doaj   +1 more source

Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer [PDF]

, 2015
Xiuxiu Chen, Fengfeng Xie, Xiu-Jie Zhu, Feng Lin, Shi-Shi Pan, Li-Hua Gong, Jian-Ge Qiu, Wenji Zhang, Qiwei Jiang, Xiao-Long Mei, Youqiu Xue, Wu-Ming Qin, Zhi Shi, Xiaojian Yan   +13 more
openalex   +1 more source

Cyclin dependent kinase 1 (CDK1) positively regulates cardiac hypertrophy and fibrosis via TGF-beta pathway [PDF]

, 2020
Tomoko Yamamoto, Shouji Matsushima, Kazuto Okabe, S Ikeda, Akihito Ishikita, Nobuyuki Enzan, Masashi Sada, Yoshitomo Tsutsui, Ryo Miyake, Hiroyuki Tsutsui   +9 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis [PDF]

, 1998
Q S Wang
openalex   +1 more source

Supplementary Figure 1 from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

, 2023
Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell, Chenguang Wang, Richard G. Pestell, Judy N. Quong, Andrew A. Quong   +7 more
openalex   +1 more source