Results 111 to 120 of about 382,305 (392)

Understanding miR‐200c: an Important Player in Resistance to Cancer Treatment

Advanced Therapeutics, EarlyView.
How can one microRNA alter cancer's response to therapy? miR‐200c plays a central role in therapeutic resistance by modulating epithelial‐mesenchymal transition, apoptosis, cancer stemness features, and drug efflux. This review outlines the context‐dependent functions of miR‐200c in various cancers and highlights its potential as both a biomarker and a
Fatma Sanli, Omer Faruk Karatas
wiley   +1 more source

Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network [PDF]

, 2010
As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although
Boruc, Joanna, De Veylder, Lieven, Hilson, Pierre, Hollunder, Jens, Inzé, Dirk, Mylle, Evelien, Rombauts, Stephane, Russinova, Eugenia, Van Den Daele, Hilde   +8 more
core   +4 more sources

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Cyclin C: The Story of a Non-Cycling Cyclin

Biology, 2019
The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression ...
Jan Ježek, Daniel G. J. Smethurst, David C. Stieg, Z. A. C. Kiss, Sara E. Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F. Cooper, Randy Strich   +8 more
doaj   +1 more source

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.

European Journal of Biochemistry, 1997
Cyclin-dependent kinases (cdk) control the cell division cycle (cdc). These kinases and their regulators are frequently deregulated in human tumours. A potent inhibitor of cdks, roscovitine [2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurin ...
W. F. Azevedo, S. Leclerc, L. Meijer, L. Havlícek, M. Strnad, Sung-Hou Kim   +5 more
semanticscholar   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis

Biochemistry and Biophysics Reports, 2016
Osteoclasts are multinucleated cells with bone resorption activity that is crucial for bone remodeling. RANK‐RANKL (receptor activator of nuclear factor κB ligand) signaling has been shown as a main signal pathway for osteoclast differentiation. However,
Yosuke Akiba, Akiko Mizuta, Yoshito Kakihara, Juri Nakata, Jun Nihara, Isao Saito, Hiroshi Egusa, Makio Saeki   +7 more
doaj   +1 more source

Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]

, 2011
A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed.
I. C. Baianu
core   +1 more source

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]

, 2014
Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian, Musgrove, Elizabeth A., Sergio, C. Marcelo, Sutherland, Robert L.   +3 more
core   +2 more sources

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma

Advanced Science, EarlyView.
CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu   +11 more
wiley   +1 more source