Structural dissection of cyclin dependent kinases regulation and protein recognition properties. [PDF]
, 2010 Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system.
LOLLI, GRAZIANO, Graziano Lolli
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Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene [PDF]
, 1995 Primary fibroblasts from patients with the genetic disease Fanconi anemia, which are hypersensitive to cross-linking agents, were used to screen a cDNA library for sequences involved in their abnormal cellular response to a cross-linking challenge.
Digweed, M. +5 more
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Cyclins, cyclin dependent kinases, and regulation of steroid receptor action [PDF]
, 2007 Steroid receptors (SR), which are ligand activated transcription factors, and their coactivators are phosphoproteins whose activities are regulated by cell signaling pathways. Many of the identified phosphorylation sites in these proteins contain Ser/Thr-
Moore, N., Weigel, N.
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Inhibition of Plk1 and Cyclin B1 expression results in panobinostat-induced G(2) delay and mitotic defects [PDF]
, 2013 Work by JP is funded by a Royal Society University Research Fellowship award. Experiments carried out by MBP were supported by the Department of Pathology, Albert Einstein College of Medicine / Montefiore Medical Center.The development of clinically ...
Parish, Joanna +9 more
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Cyclin-dependent kinases: Masters of the eukaryotic universe. [PDF]
Wiley Interdiscip Rev RNA, 2023 Pluta AJ +3 more
europepmc +1 more source
Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]
, 2003 The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
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Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells
The EMBO JournalCDK7 has emerged as a cancer target because of its pivotal roles in cell cycle progression and transcription. Several CDK7 inhibitors (CDK7i) are now in clinical evaluation.
Chun-Fui Lai +7 more
doaj +1 more source
Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. [PDF]
Proc Natl Acad Sci U S A, 2023 Dunbar KL +11 more
europepmc +1 more source
The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis [PDF]
, 2004 Cyclin-dependent kinases (CDKs) play essential roles in coordinate control of cell cycle progression. Activation of CDKs requires interaction with specific cyclin partners and phosphorylation of their T-loops by CDK-activating kinases (CAKs).
Akie Shimotohno +5 more
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The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer. [PDF]
Int J Mol Sci, 2023 Javed A +3 more
europepmc +1 more source