Results 71 to 80 of about 3,178,268 (185)
Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates [PDF]
, 2010 The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several phases,
Sadowski, Martin +2 more
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The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis
Biochemistry and Biophysics Reports, 2016 Osteoclasts are multinucleated cells with bone resorption activity that is crucial for bone remodeling. RANK‐RANKL (receptor activator of nuclear factor κB ligand) signaling has been shown as a main signal pathway for osteoclast differentiation. However,
Yosuke Akiba +7 more
doaj +1 more source
, 2009 Supplementary Data from Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell ...
Neil T. Thompson (5322431) +7 more
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GPRIN1 enhances gallbladder cancer progression and is associated with the CDK1 pathway
Cancer Biology & TherapyG protein-regulated inducer of neurite outgrowth 1 (GPRIN1), a predominantly membrane-bound protein highly enriched in neurite growth cones and neurite outgrowth, plays a crucial role in neuronal network development.
Min Li +8 more
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Cyclin-dependent kinases: Masters of the eukaryotic universe. [PDF]
Wiley Interdiscip Rev RNA, 2023 Pluta AJ +3 more
europepmc +1 more source
Targets of cyclin-dependent protein kinases
, 1993 Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation ...
Nigg, E. A.
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Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells
The EMBO JournalCDK7 has emerged as a cancer target because of its pivotal roles in cell cycle progression and transcription. Several CDK7 inhibitors (CDK7i) are now in clinical evaluation.
Chun-Fui Lai +7 more
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, 2012 Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates.
Pagano, M +2 more
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JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]
, 2006 MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
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Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell [PDF]
, 2010 Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge +5 more
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