The role of anchorage in cell cycle control [PDF]
, 2009 Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint ...
Cremona, C.A.
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Normal levels of p27Xic1 are necessary for somite segmentation and determining pronephric organ size [PDF]
, 2009 The Xenopus laevis cyclin dependent kinase inhibitor p27Xic1 has been shown to be involved in exit from the cell cycle and differentiation of cells into a quiescent state in the nervous system, muscle tissue, heart and retina.
Collins, R.J. +7 more
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JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]
, 2006 MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
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Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts [PDF]
, 1992 . In eukaryotic ells, the onset of mitosis in-volves cyclin molecules which interact with proteins of the cdc2 family to produce active kinases. In verte-brate cells, cyclin A dependent kinases become active in S- and pro-phases, whereas a cyclin B ...
Eric Karsenti +14 more
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A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. [PDF]
, 2012 Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates.
Pagano, M +3 more
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Viruses, 2015 Replication of human cytomegalovirus (HCMV) is characterized by a tight virus-host cell interaction. Cyclin-dependent protein kinases (CDKs) are functionally integrated into viral gene expression and protein modification.
Mirjam Steingruber +7 more
doaj +1 more source
Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]
, 1995 Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J. +2 more
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A cell cycle-regulated inhibitor of cyclin-dependent kinases [PDF]
, 1994 International audienceCyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans.
Hengst, L +7 more
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Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell [PDF]
, 2010 Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge +5 more
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Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates [PDF]
, 2010 The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates cell division from simple unicellular organisms, such as yeast, through to higher multicellular organisms, such as humans. The cell cycle comprises several phases,
Sadowski, Martin +2 more
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