Results 121 to 130 of about 382,305 (392)
PRACTICAL ASPECTS OF ADMINISTERING CYCLIN-DEPENDENT KINASES INHIBITORS: EFFICACY AND TOLERABILITY
Опухоли женской репродуктивной системы, 2018 Although metastatic breast cancer remains an incurable disease, significant achievements have been made in this area over the recent years, allowing to convert breast cancer into a chronically controlled disease characterized by a torpid course. Patients
E. V. Artamonova
doaj +1 more source
Cyclin-Dependent Kinases: CAK-handed kinase activation [PDF]
Current Biology, 1995 A protein kinase that activates cyclin-dependent kinases has been identified as a related catalytic subunit in association with a novel cyclin regulatory subunit--it is itself a cyclin-dependent kinase.
openaire +3 more sources
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards.
, 2008 In: Li JJ, Li SA, Mohla S, Rochefort H, Maudelonde T, (eds), 2008, Hormonal Carcinogenesis V : Proceedings of the Fifth International Symposium, New York, Springer-Verlag. (Adv. Exp. Med. Biol.
Prigent, Claude +2 more
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Advanced Science, EarlyView.This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu +7 more
wiley +1 more source
Inhibition of cyclin-dependent kinases by purine analogues.
European Journal of Biochemistry, 1994 While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2 ...
J. Veselý +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.SIRT3 expression is significantly downregulated in the aged kidney, rendering the kidney more vulnerable to fibrotic changes in obstructive nephropathy. By promoting GSK‐3β deacetylation, SIRT3 indirectly inhibits Wnt/β‐catenin signaling, thereby suppressing renal fibrosis.
Jing Wang +11 more
wiley +1 more source
Middle East Journal of Cancer, 2017 Background: The current study investigated the possible role of the cell cycle regulator, cyclin-dependent kinases regulatory subunit-2; the angiogenic factor, plateletderived endothelial cell growth factor; and the cell adhesive molecule, neural ...
Sanaa Shawky +5 more
doaj
Reversal of terminal differentiation and control of DNA replication [PDF]
, 1993 DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina +2 more
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Advanced Science, EarlyView.This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang +9 more
wiley +1 more source