Results 141 to 150 of about 3,178,268 (185)
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Inhibitors of cyclin-dependent kinase and cancer
Journal of Molecular Medicine, 1995Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
J R, Biggs, A S, Kraft
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Designing Inhibitors of Cyclin-Dependent Kinases
Annual Review of Pharmacology and Toxicology, 2002Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Ian R, Hardcastle +2 more
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Cyclin-Dependent Kinase Inhibition by Flavoalkaloids
Mini-Reviews in Medicinal Chemistry, 2012Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
S K, Jain +2 more
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Quinazolines as cyclin dependent kinase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2001Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
T M, Sielecki +14 more
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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors
2023Nathan H. Lents +1 more
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Chemical inhibitors of cyclin-dependent kinases
Trends in Cell Biology, 1995The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
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Cyclin-Dependent Kinases and Cell-Cycle Transitions: Does One Fit All?
Nature Reviews Molecular Cell Biology, 2008Tim Hunt +2 more
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