Results 161 to 170 of about 114,714 (200)

Pharmacological inhibitors of cyclin-dependent kinases

Trends in Pharmacological Sciences, 2002
Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. Deregulation of CDKs in various diseases has stimulated an intensive search for selective pharmacological inhibitors of these kinases.
Paul Greengard, Laurent Meijer, Marie Knockaert   +2 more
exaly   +3 more sources

Inhibitors of cyclin-dependent kinase and cancer

Journal of Molecular Medicine, 1995
Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
J R, Biggs, A S, Kraft
openaire   +2 more sources

Designing Inhibitors of Cyclin-Dependent Kinases

Annual Review of Pharmacology and Toxicology, 2002
Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Ian R, Hardcastle, Bernard T, Golding, Roger J, Griffin   +2 more
openaire   +2 more sources

Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
S K, Jain, S B, Bharate, R A, Vishwakarma   +2 more
openaire   +2 more sources

Quinazolines as cyclin dependent kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2001
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
T M, Sielecki, T L, Johnson, J, Liu, J K, Muckelbauer, R H, Grafstrom, S, Cox, J, Boylan, C R, Burton, H, Chen, A, Smallwood, C H, Chang, M, Boisclair, P A, Benfield, G L, Trainor, S P, Seitz   +14 more
openaire   +2 more sources

Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A, Ubersax, Erika L, Woodbury, Phuong N, Quang, Maria, Paraz, Justin D, Blethrow, Kavita, Shah, Kevan M, Shokat, David O, Morgan   +7 more
openaire   +2 more sources

Identification of substrates for cyclin dependent kinases

Advances in Enzyme Regulation, 2010
Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes. From yeast to humans, cell cycle progression and cell division require the activation of a group of serine– threonine protein kinases called cyclin dependent kinases (CDKs) (Morgan, 1997), which initiate and coordinate these processes by orderly phosphorylation ...
Errico, A., Deshmukh, K., Tanaka, Y., Pozniakovsky, A., Hunt, T.   +4 more
openaire   +3 more sources

Cyclins, cyclin‐dependent kinases and differentiation

BioEssays, 1997
AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
C Y, Gao, P S, Zelenka
openaire   +2 more sources

Chemical inhibitors of cyclin-dependent kinases

Trends in Cell Biology, 1995
The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
openaire   +3 more sources

Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors

2023
Nathan H. Lents, Richard T. Piszczatowski   +1 more
openaire   +1 more source