Results 161 to 170 of about 2,935,830 (275)

Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2− metastatic breast cancer: a focus on ribociclib

, 2017
Dumessa Edessa,1 Mekonnen Sisay2 1Department of Pharmacy Practice, 2Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Oromia, Ethiopia Abstract: In normal cell cycle progression ...
Sisay M, Edessa D
core  

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

When cyclin-dependent kinases meet viral infections, including SARS-CoV-2. [PDF]

J Med Virol, 2022
Yan Y, Tang YD, Zheng C.
europepmc   +1 more source

Mechanistic Roles of Transcriptional Cyclin-Dependent Kinases in Oncogenesis: Implications for Cancer Therapy. [PDF]

Cancers (Basel)
Alrouji M, Alshammari MS, Anwar S, Venkatesan K, Shamsi A.   +4 more
europepmc   +1 more source

Comprehensive Analysis of Role of Cyclin-Dependent Kinases Family Members in Colorectal Cancer. [PDF]

Front Oncol, 2022
Guan L, Tang Y, Li G, Qin Z, Li S.
europepmc   +1 more source

Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase. [PDF]

Proc Natl Acad Sci U S A
Koyanagi N, Hengphasatporn K, Kato A, Nobe M, Takeshima K, Maruzuru Y, Maenaka K, Shigeta Y, Kawaguchi Y.   +8 more
europepmc   +1 more source

Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-<i>c</i>]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases. [PDF]

Molecules, 2023
Zheng D, Yang C, Li X, Liu D, Wang Y, Wang X, Zhang X, Tan Y, Zhang Y, Li Y, Xu J.   +10 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Differential activity of specific inhibitors of transcription regulating cyclin-dependent kinases in thyroid cancer cells. [PDF]

Endocr Relat Cancer
Rajan N, Khanal T, Adik A, Valenciaga A, Nigam A, Liyanarachchi S, Ringel MD.   +6 more
europepmc   +1 more source

Second Breast‐Conserving Treatment for Ipsilateral Breast Tumor Recurrence: A Review of Patient Selection, Reirradiation Techniques, and Clinical Outcomes

International Journal of Cancer, EarlyView.
ABSTRACT Local recurrence after primary breast cancer treatment remains a complex clinical scenario in patients previously treated with breast‐conserving therapy and radiotherapy. For decades, salvage mastectomy was considered the standard treatment for ipsilateral breast tumor recurrence, largely because of concerns about local control after repeat ...
Cezara Cheptea, Youlia Kirova, Radu Iulian Mitrica, Mihaela Badea, Pierre Loap   +4 more
wiley   +1 more source