Results 161 to 170 of about 152,628 (302)

Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities. [PDF]

J Cancer Res Clin Oncol, 2023
Zabihi M, Lotfi R, Yousefi AM, Bashash D.   +3 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases. [PDF]

Sci Transl Med, 2023
Kartha N, Gianopulos JE, Schrank Z, Cavender SM, Dobersch S, Kynnap BD, Wallace-Povirk A, Wladyka CL, Santana JF, Kim JC, Yu A, Bridgwater CM, Fuchs K, Dysinger S, Lampano AE, Notta F, Price DH, Hsieh AC, Hingorani SR, Kugel S.   +19 more
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

The Emerging Role of Transcription-Associated Cyclin-Dependent Kinases in Gastrointestinal Tumors. [PDF]

Cancers (Basel)
Athavale D, Pulipati D, Balch C, Zhao J, Zhang Y, Yao X, Song S.   +6 more
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Targeting Transcriptional Cyclin-Dependent Kinases in Cancer. [PDF]

Mol Cancer Ther
Kolodziejczyk A, Sicinski P.
europepmc   +1 more source

Transcription associated cyclin-dependent kinases as therapeutic targets for prostate cancer. [PDF]

Oncogene, 2022
Constantin TA, Greenland KK, Varela-Carver A, Bevan CL.   +3 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Transcriptional cyclin-dependent kinases Cdk8 and Cdk19 are required for normal macrophage differentiation. [PDF]

Cell Cycle
Kolodziejczyk A, Liu S, Strobel F, Martinez Alonso D, Butter D, Śnioch K, Chu C, Long H, Sexl V, Qiang L, Qiang L, Dougan SK, Sicinski P.   +12 more
europepmc   +1 more source