Results 171 to 180 of about 114,587 (298)

Targeting Transcriptional Cyclin-Dependent Kinases in Cancer. [PDF]

Mol Cancer Ther
Kolodziejczyk A, Sicinski P.
europepmc   +1 more source

Seminars in epileptology: Holistic management of epilepsy in adults with intellectual development disorders

Epileptic Disorders, EarlyView.
Abstract This seminar addresses the complexity of the management of epilepsy in adults with intellectual development disorders (IDD), advocating holistic and multidisciplinary care aligned with the learning objectives of the International League Against Epilepsy. Epilepsy is significantly more prevalent in people with IDD, presenting unique diagnostic,
Elena Fonseca, Antonella Riva, Samuel López‐Maza, Malin Zaddach, Marie‐Claire Porter, Ingo Borggraefe, Lance Watkins, Andreas Schulze‐Bonhage, Rohit Shankar, Pasquale Striano, Lina Nashef   +10 more
wiley   +1 more source

Transcriptional cyclin-dependent kinases Cdk8 and Cdk19 are required for normal macrophage differentiation. [PDF]

Cell Cycle
Kolodziejczyk A, Liu S, Strobel F, Martinez Alonso D, Butter D, Śnioch K, Chu C, Long H, Sexl V, Qiang L, Qiang L, Dougan SK, Sicinski P.   +12 more
europepmc   +1 more source

Transcription associated cyclin-dependent kinases as therapeutic targets for prostate cancer. [PDF]

Oncogene, 2022
Constantin TA, Greenland KK, Varela-Carver A, Bevan CL.   +3 more
europepmc   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

When cyclin-dependent kinases meet viral infections, including SARS-CoV-2. [PDF]

J Med Virol, 2022
Yan Y, Tang YD, Zheng C.
europepmc   +1 more source

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source

Mechanistic Roles of Transcriptional Cyclin-Dependent Kinases in Oncogenesis: Implications for Cancer Therapy. [PDF]

Cancers (Basel)
Alrouji M, Alshammari MS, Anwar S, Venkatesan K, Shamsi A.   +4 more
europepmc   +1 more source

Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-<i>c</i>]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases. [PDF]

Molecules, 2023
Zheng D, Yang C, Li X, Liu D, Wang Y, Wang X, Zhang X, Tan Y, Zhang Y, Li Y, Xu J.   +10 more
europepmc   +1 more source

Synthesis of the small peptide analogues of cyclin dependent kinase (CDK4) for cancer treatment

Cyclin-dependent kinases (CDKs) are a group of enzymes that are involved in cell cycle progression regulation. The CDKs activate host proteins through phosphorylation on serine or threonine using adenosine triphosphate as a phosphate donor.
Romsaiyud, Jariya
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