Results 171 to 180 of about 114,714 (200)

p27KIP1, an inhibitor of cyclin-dependent kinases

1995
The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
A, Koff, K, Polyak
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Smad3 phosphorylation by cyclin-dependent kinases

Cytokine & Growth Factor Reviews, 2006
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
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The dynamics of cyclin dependent kinase structure

Current Opinion in Cell Biology, 1996
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
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Measuring Cyclin-Dependent Kinase Activity

2004
The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
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Cyclin-Dependent Kinases

2008
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Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

Chemistry and Biology, 2000
E M Mandelkow, L H Tsai
exaly  

Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression

Trends in Pharmacological Sciences, 2016
M Lienhard Schmitz, Michael Kracht
exaly  

Control of the G1 phase cyclin-dependent kinases by mitogenic growth factors and the extracellular matrix

Cytokine and Growth Factor Reviews, 1997
Richard K Assoian, R K Assoian
exaly  

Activation of the Cdc42p GTPase by cyclin‐dependent protein kinases in budding yeast

EMBO Journal, 2007
Brenda Andrews, Daniel Figeys, Richelle Sopko   +2 more
exaly  

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

Nature Reviews Molecular Cell Biology, 2008
Tim Hunt, Helfrid Hochegger, Shunichi Takeda   +2 more
exaly