Results 151 to 160 of about 2,935,830 (275)

Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities. [PDF]

J Cancer Res Clin Oncol, 2023
Zabihi M, Lotfi R, Yousefi AM, Bashash D.   +3 more
europepmc   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Modular Synthesis of Di‐ and Triazadibenzoazulenes by a Cross‐Coupling/Cycloisomerization Strategy

European Journal of Organic Chemistry, EarlyView.
Two series of regioisomeric di‐ and triazadibenzoazulenes were prepared from dihalogenated imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines. Imidazo[1,2‐a]pyridines and imidazo[1,2‐a]pyrazines are important nitrogen‐containing heterocycles with applications in medicinal and materials chemistry.
Karyna Kulyk, Artyom Petrosyan, Karsten Paul Lüdtke, Jonas Surkau, Martin Köckerling, Peter Ehlers, Peter Langer   +6 more
wiley   +1 more source

Targeting Transcriptional Cyclin-Dependent Kinases in Cancer. [PDF]

Mol Cancer Ther
Kolodziejczyk A, Sicinski P.
europepmc   +1 more source

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases. [PDF]

Sci Transl Med, 2023
Kartha N, Gianopulos JE, Schrank Z, Cavender SM, Dobersch S, Kynnap BD, Wallace-Povirk A, Wladyka CL, Santana JF, Kim JC, Yu A, Bridgwater CM, Fuchs K, Dysinger S, Lampano AE, Notta F, Price DH, Hsieh AC, Hingorani SR, Kugel S.   +19 more
europepmc   +1 more source

Electroclinical phenotypes—genetic characterization of developmental and epileptic encephalopathies in a cohort study

Epileptic Disorders, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman, Fulya Kurekci, Sinan Akbas, Ceyda Oney, Mehmet Akif Kilic, Hulya Maras Genc, Ayca Dilruba Aslanger, Edibe Pembegul Yildiz   +7 more
wiley   +1 more source

Cyclin-Dependent Kinases 4 and 6 Inhibitors: An Emerging Therapeutic Framework from Growth Suppression to Tumor Clearance. [PDF]

ACS Pharmacol Transl Sci
Ma C, Ji X, Huang W, Guo S, Wang L, Wu X, Zheng H, Wang J.   +7 more
europepmc   +1 more source

Under‐Explored Species, Breeds and Cell Types With Potential for Cultivated Meat Production

Food Bioengineering, EarlyView.
This graphical abstract illustrates how the strategic selection of overlooked cell lines from novel species and specific agricultural breeds can help overcome current manufacturing bottlenecks in cultivated meat production. The schematic links the concept of an ‘ideal cell line’ to four key bioprocessing and product advantages that can be optimised ...
William Gordon‐Petrovskii, Maanasa Ravikumar, Travis Callue, Maria Laura Vieri, Michael Sulu, Gary J. Lye, Mariana Petronela Hanga   +6 more
wiley   +1 more source

Transcriptional cyclin-dependent kinases Cdk8 and Cdk19 are required for normal macrophage differentiation. [PDF]

Cell Cycle
Kolodziejczyk A, Liu S, Strobel F, Martinez Alonso D, Butter D, Śnioch K, Chu C, Long H, Sexl V, Qiang L, Qiang L, Dougan SK, Sicinski P.   +12 more
europepmc   +1 more source

Transcription associated cyclin-dependent kinases as therapeutic targets for prostate cancer. [PDF]

Oncogene, 2022
Constantin TA, Greenland KK, Varela-Carver A, Bevan CL.   +3 more
europepmc   +1 more source