Results 131 to 140 of about 382,305 (392)

Cyclin-dependent kinases: Masters of the eukaryotic universe. [PDF]

Wiley Interdiscip Rev RNA, 2023
Pluta AJ, Studniarek C, Murphy S, Norbury CJ.   +3 more
europepmc   +1 more source

DNA damage stress: Cui prodest? [PDF]

, 2019
DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha, Franchitto, Matteo, Palermo, Rocco, Talora, Claudio, Verma, Nagendra, Zonfrilli, Azzurra   +5 more
core   +1 more source

Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer

Advanced Science, EarlyView.
In the study, UBE2C was found to be significantly overexpressed in breast cancer and transcriptionally regulated by FOXM1. Inhibition of UBE2C suppressed proliferation, induced senescence, and sensitized breast cancer cells to doxorubicin. Mechanistically, UBE2C inhibition promoted Parkin‐mediated K63‐linked ubiquitination of TOP2A.
Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang, Guanhua Du, Yumin Wang, Jinhua Wang   +12 more
wiley   +1 more source

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. [PDF]

, 1994
Jun‐ya Kato, Masao Matsuoka, David K. Strom, Charles J. Sherr   +3 more
openalex   +1 more source

Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis [PDF]

, 2004
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in ...
Baianu, Professor I.C., Prisecaru, M.S. V   +1 more
core  

Transferring an optimized TAP-toolbox for the isolation of protein complexes to a portfolio of rice tissues [PDF]

, 2016
Proteins are the cell's functional entities. Rather than operating independently, they interact with other proteins. Capturing in vivo protein complexes is therefore crucial to gain understanding of the function of a protein in a cellular context ...
Cannoot, Bernard, De Jaeger, Geert, De Winne, Nancy, Dedecker, Maarten, Dumoulin, Lies, Eeckhout, Dominique, Gevaert, Kris, Persiau, Geert, Van De Slijke, Eveline, Van Leene, Jelle, Vandenabeele, Steven, Vercruysse, Leen, Wojsznis, Nathalie   +12 more
core   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Genes & Development, 2010
Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly.
K. Labib
semanticscholar   +1 more source

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Berberich, Nina, Fürst, Robert, Joore, Jos, Khandoga, Alexander G., Krombach, Fritz, Mayer, Bettina A., Sass, Gabriele, Schmerwitz, Ulrike K., Tiegs, Gisa, Totzke, Frank, Vollmar, Angelika M., Zahler, Stefan   +11 more
core   +1 more source

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source