Results 111 to 120 of about 345,409 (245)
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source
Advanced Science, EarlyView.During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li +15 more
wiley +1 more source
Advanced Science, EarlyView.Carbon nanosol (CNS) exhibits rapid root penetration capacity, enhancing plant growth through boosting stomatal density and antioxidative enzyme activity. Single‐cell transcriptomic profiling uncovers cell type‐specific gene expression patterns and developmental trajectories during CNS‐mediated growth promotion.
Lingtong Cheng +10 more
wiley +1 more source
Advanced Science, EarlyView.A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding +7 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
Growth Charts for Children With Beckwith–Wiedemann Spectrum
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Beckwith–Wiedemann spectrum (BWSp) is an overgrowth disorder caused by (epi)genetic alterations in chromosome 11p15. This study aimed to develop BWSp‐specific growth charts and explore genotype/phenotype correlations with respect to growth. Heights, weights, and head circumferences were retrospectively collected from 581 individuals with BWSp ...
Saskia M. Maas +11 more
wiley +1 more source
Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]
, 1995 Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R. +2 more
core
Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source
Cyclins and cyclin-dependent kinases: a biochemical view [PDF]
Biochemical Journal, 1995 openaire +3 more sources