Results 211 to 220 of about 406,416 (358)

Supplementary Figure 6 from Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells

, 2023
Emilio Cosimo, Alison M. McCaig, Luke J.M. Carter-Brzezinski, Helen Wheadon, Michael T. Leach, Karine Le Ster, Christian Berthou, Émilie Durieu, Nassima Oumata, Hervé Galons, Laurent Meijer, Alison M. Michie   +11 more
openalex   +1 more source

Underutilization of syndrome‐specific ICD‐10 codes for genetic epilepsies: Implications for precision medicine

Epilepsia, EarlyView.
Abstract Syndrome‐specific International Classification of Diseases, 10th Revision (ICD‐10) codes have the potential to improve identification of patients for precision therapies, clinical trials, and research, yet their real‐world uptake is not well characterized.
Émile Moura Coelho da Silva, Tobias Brünger, Gary Taylor, Mousumi Sinha, Alison Merket, Anu Cherukara, Sunanjay Bajaj, Jessica Clark, Ludovica Montanucci, Emily A. Huth, Mariana Fauteux, Samden D. Lhatoo, Christian M. Boßelmann, Costin Leu, Rahil A. Tai, Dennis Lal   +15 more
wiley   +1 more source

Discovery of a First-in-Class Murine Double Minute 2-Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor Activity. [PDF]

MedComm (2020)
Guan X, Xie L, Guo H, Ma L, Zhou J, Luo L, Yang H, Wu Y, Liu J, Wang Y, Huang X, Liu J, Zhang Y, Chen W, Chen Y, Xu L, Han X.   +16 more
europepmc   +1 more source

Figure S13-S16 from Cyclin E Overexpression Sensitizes Triple-Negative Breast Cancer to Wee1 Kinase Inhibition

, 2023
Xian Chen, Kwang-Huei Low, Angela Alexander, Yufeng Jiang, Cansu Karakaş, Kenneth R. Hess, Jason P.W. Carey, Tuyen Bui, Smruthi Vijayaraghavan, Kurt W. Evans, Min Yi, D. Christian Ellis, Kwok‐Leung Cheung, Ian O. Ellis, Siqing Fu, Funda Meric‐Bernstam, Kelly K. Hunt, Khandan Keyomarsi   +17 more
openalex   +1 more source

Mental health impacts experienced by caregivers of people with Dravet syndrome: A systematic literature review

Epilepsia, EarlyView.
Graphical abstract for the systematic literature review. Abstract Objective Dravet syndrome (DS) places tremendous burden on caregivers owing to the extent of required assistance and impact on daily living, as well as the risk to the individual with DS of premature mortality from sudden unexpected death in epilepsy and morbidity associated with ...
Adam Strzelczyk, Mary Anne Meskis, Galia Wilson, Bobby Jacob, Christoph Helmstaedter, Jane von Gaudecker, Veronica Hood, Ceri Hughes, Michael Scott Perry   +8 more
wiley   +1 more source

Cyclin-E/A/CDK1/2 Kinetic Landscapes Drive Cell Cycle Phase-Specific Progression and Guide Cyclin-E Degradation Strategy. [PDF]

J Chem Inf Model
Zhang W, Bradburn D, Liu Y, Jang H, Kõivomägi M, Nussinov R.   +5 more
europepmc   +1 more source

Data from Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells

, 2023
Emilio Cosimo, Alison M. McCaig, Luke J.M. Carter-Brzezinski, Helen Wheadon, Michael T. Leach, Karine Le Ster, Christian Berthou, Émilie Durieu, Nassima Oumata, Hervé Galons, Laurent Meijer, Alison M. Michie   +11 more
openalex   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source

Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy. [PDF]

Cancer Res
Rubin SM, Sage J, Skotheim JM.
europepmc   +1 more source

卵巣内におけるSerum- and glucocorticoid-regulated kinase (SGK)による細胞内pH上昇とcyclin B-Cdk1活性化を介したヒトデ卵第一減数分裂の制御機構［学位論文内容の要旨/学位論文審査の要旨/日本語要旨/外国語要旨］ [PDF]

, 2019
絵奈子 細田
openalex