Theoretical dynamics of the cyclin B-MPF system: a possible role for p13suc1
, 1994 C.D. Thron
openalex +1 more source
BioEssays, EarlyView.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis. [PDF]
Commun Biol, 2020 Rosendo-Pineda MJ +8 more
europepmc +1 more source
A Specific Inhibitor of p34cdc2/Cyclin B Suppresses Fertilization-Induced Calcium Oscillations in Mouse Eggs1 [PDF]
, 2000 Manqi Deng, Sheldon S. Shen
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Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing
BioEssays, EarlyView.Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck +1 more
wiley +1 more source
The Expression of p18INK4 and p27kip1 Cyclin-Dependent Kinase Inhibitors Is Regulated Differently During Human B Cell Differentiation [PDF]
, 2000 Nicolas Schrantz +5 more
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Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, EarlyView.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source
Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast
, 1997 Angelika Amon
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Dynamic protein interactions probed by NMR spectroscopy
Bulletin of the Korean Chemical Society, EarlyView.Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley +1 more source
Two-Step Mechanism of Cyclin B Degradation Initiated by Proteolytic Cleavage with the 26 S Proteasome in Fish. [PDF]
Sci Rep, 2020 Tokumoto T +7 more
europepmc +1 more source