Results 301 to 310 of about 12,781,724 (361)

Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells.

, 1993
Andrew L. Kung, Steven W. Sherwood, Robert Schimke   +2 more
openalex   +1 more source

Case Report and Literature Review: Intrathyroid Thymic Carcinoma

Journal of Clinical Ultrasound, EarlyView.
This case report highlights the challenges in diagnosing intrathyroid thymic carcinoma (ITTC), a rare thyroid tumor, and underscores the importance of postoperative pathology for confirmation. The study emphasizes the good prognosis of ITTC with appropriate surgical management.
Jia‐Yue Sun, Ji Qi, Yi‐Lin Hou, Yun‐Fei Zhang   +3 more
wiley   +1 more source

Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design

Huan He, Xingsen Zhang, Jie Wang, Qi Liu, Leihao Zhang, Lü Chen, Yuan Yuan, Zhenjiang Zhao, Honglin Li, Zhuo Chen   +9 more
openalex   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis

Journal of Ultrasound in Medicine, EarlyView.
Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault, Lenin Chinchilla, Lourdes Massengo, Pierre Monbernard, Fadila Benhamed, Marion Regnier, Raphael Denis, Catherine Postic, Anthony Novell, Jean‐Luc Gennisson   +9 more
wiley   +1 more source

GLIS2 Promotes Epithelial‐Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial‐mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β‐catenin stimulation. By analyzing 18 pairs of GC tissues and establishing in vitro models (combining GLIS2 knockdown/BGN overexpression with Wnt pathway ...
Juan Yan, Ya‐Peng Deng
wiley   +1 more source

Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system

, 2016
Salma Al Dallal, Kathryn Wolton, Kathryn E. Hentges   +2 more
openalex   +1 more source

Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is known to promote muscle wasting and cellular senescence, largely by impairing mitochondrial function.
Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo   +6 more
wiley   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source