Results 341 to 350 of about 12,781,724 (361)
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Homology Model of the CDK1/cyclin B Complex
Journal of Biomolecular Structure and Dynamics, 2005We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Connor F, McGrath +7 more
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Cyclin D1 regulates p27Kip1 stability in B cells
Cellular Signalling, 2011p27(Kip1) is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S transition, and whose activity is, in part, regulated through interactions with D-type cyclins. We have generated the BD1-9 cell line, a BaF3 pro-B cells derivative in which cyclin D1 can be induced rapidly and reversibly by ponasterone A.
S, Bustany +2 more
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The EMBO Journal, 1994
Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cdk1/cyclin B‐mediated phosphorylation regulates SREBP1
The FASEB Journal, 2007The sterol regulatory element‐binding protein (SREBP) family of transcription factors controls the biosynthesis of cholesterol and other lipids, and lipid synthesis is critical for cell growth and proliferation. We have found that the mature forms of SREBP1a and SREBP1c are hyperphosphorylated in mitotic cells, giving rise to a phosphoepitope ...
Maria Teresa Bengoechea‐Alonso +1 more
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Increase of cyclin B by overexpression of cystatin α
Cell Biochemistry and Function, 1995AbstractDegradation of cyclin B was effectively suppressed when cells were treated with ALLN (N‐acetylleucylleucylnorleucinal) which inhibits proteasome, calpain and cysteine proteinase cathepsins. In order to examine which protease degrades cyclin B, the effect of a cathepsin inhibitor, cystatin α, was investigated.
T, Hiwasa +4 more
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Biology of the Cell, 1998
We reconsider the notion of MPF initiation, which is generally viewed as the prerequisite production of a small cdc2‐cyclin B kinase activity sufficient to trigger its own self‐amplification. Using starfish oocytes as a tool, we show that H1 kinase activation is not explosive, but rather is a gradual process in both time and space. We show further that
A, Picard, G, Peaucellier
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We reconsider the notion of MPF initiation, which is generally viewed as the prerequisite production of a small cdc2‐cyclin B kinase activity sufficient to trigger its own self‐amplification. Using starfish oocytes as a tool, we show that H1 kinase activation is not explosive, but rather is a gradual process in both time and space. We show further that
A, Picard, G, Peaucellier
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Journal of Cell Science, 1995
ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M. +6 more
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ABSTRACT We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin B3 is less related to these cyclins. However, this cyclin is most similar to the recently identified chicken cyclin B3.
Kreutzer, M. +6 more
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The Journal of Immunology, 2006
Abstract Peritoneal B-1a cells differ from splenic B-2 cells in the molecular mechanisms that control G0-S progression. In contrast to B-2 cells, cyclin D2 is up-regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cyclin D3 does not accumulate until late G1 phase. This nonoverlapping expression
Jennifer M, Mataraza +5 more
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Abstract Peritoneal B-1a cells differ from splenic B-2 cells in the molecular mechanisms that control G0-S progression. In contrast to B-2 cells, cyclin D2 is up-regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cyclin D3 does not accumulate until late G1 phase. This nonoverlapping expression
Jennifer M, Mataraza +5 more
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[Cyclins A and B: redundancy and specificity].
Pathologie-biologie, 1994Mitotic cyclins constitute a regulatory subunit of the histone H1 kinase complex. On the basis of primary structure differences, they are divided into two classes, A and B. Both classes are necessary for mitosis to occur. Cyclins A and B differ in the timing of their cellular expression and in their affinity with the various members of the cdk (cyclin ...
D, Wolowiec, M, Ffrench
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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
Science, 1992Laura L. Parker, H. Piwnica-Worms
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