Results 371 to 380 of about 13,616,352 (396)
Cyclin D1 expression in B-cell lymphomas [PDF]
Experimental Hematology, 2010 Cyclin D1, an important component of cell cycle machinery and a protein with known oncogenic potential, is downregulated in normal mature B lymphocytes. Its expression detected in a number of malignancies, including B-cell lymphomas, may be important for oncogenesis.In our work, we determined the level of cyclin D1 expression in various B-cell ...
Aleena Gladkikh +4 more
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Homology Model of the CDK1/cyclin B Complex [PDF]
Journal of Biomolecular Structure and Dynamics, 2005 We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Nagarajan Pattabiraman +7 more
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The EMBO Journal, 1994
Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.
Science, 1992Entry into mitosis in Schizosaccharomyces pombe is negatively regulated by the wee1+ gene, which encodes a protein kinase with serine-, theonine-, and tyrosine-phosphorylating activities.
Laura L. Parker, H. Piwnica-Worms
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Cyclin A and B functions in the early Drosophila embryo [PDF]
Development, 1999 Abstract In eukaryotes, mitotic cyclins localize differently in the cell and regulate different aspects of the cell cycle. We investigated the relationship between subcellular localization of cyclins A and B and their functions in syncytial preblastoderm Drosophila embryos.
Susanne Trautmann +4 more
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Increase of cyclin B by overexpression of cystatin α
Cell Biochemistry and Function, 1995AbstractDegradation of cyclin B was effectively suppressed when cells were treated with ALLN (N‐acetylleucylleucylnorleucinal) which inhibits proteasome, calpain and cysteine proteinase cathepsins. In order to examine which protease degrades cyclin B, the effect of a cathepsin inhibitor, cystatin α, was investigated.
Nobuhiko Katunuma +4 more
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Porcine CPEB1 is involved in Cyclin B translation and meiotic resumption in porcine oocytes.
Animal science journal = Nihon chikusan Gakkaiho, 2010Ovarian immature oocytes accumulate many dormant maternal mRNAs, which have short poly(A) tails. Cytoplasmic-polyadenylation-element binding protein (CPEB) has been reported to play key roles for the elongation of the tails and the translation of these ...
Yukio Nishimura, K. Kano, K. Naito
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