Results 71 to 80 of about 13,561,237 (381)

Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1/CYCLIN B

open access: yesPLoS ONE, 2011
Although the AIB1 oncogene has an important role during the early phase of the cell cycle as a coactivator of E2F1, little is known about its function during mitosis.Mitotic cells isolated by nocodazole treatment as well as by shake-off revealed a post-translational modification occurring in AIB1 specifically during mitosis.
Ferrero, Macarena   +6 more
openaire   +9 more sources

Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma

open access: yesHaematologica, 2009
In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations.
Inga Nagel   +9 more
doaj   +1 more source

Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation [PDF]

open access: yes, 2018
p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell division progresses when stably Cdk2$/$cyclin A-bound p27 is phosphorylated on one or two structurally ...
arxiv   +1 more source

Intercalative DNA binding of the marine anticancer drug variolin B [PDF]

open access: yes, 2017
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown.
Albericio Palomera, Fernando   +5 more
core   +3 more sources

Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

open access: yesCell Reports, 2020
Summary: Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins.
Parham Ramezani-Rad   +3 more
doaj  

Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]

open access: yesJournal of Medicinal Chemistry 49, 5141-5153 (2006), 2008
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv   +1 more source

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins [PDF]

open access: yes, 2015
Mutant p53 proteins are present in more than half of human cancers. Yes-associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer.
Bicciato, Silvio   +9 more
core   +1 more source

Cyclin B-Cdk1 Controls Pronuclear Union in Interphase [PDF]

open access: yesCurrent Biology, 2008
In sexual reproduction, the union of the male and female pronuclei occurs in fertilized eggs to mix genetic materials derived from both parents, thereby creating a new genome for the next generation [1-4]. The process leading to pronuclear union consists of pronuclear congression, which depends on astral microtubules derived from sperm centrosome [5-8],
Kazunori Tachibana   +3 more
openaire   +3 more sources

Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma

open access: yesAnnals of Agricultural and Environmental Medicine, 2015
[b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska   +5 more
doaj   +1 more source

Using a hydrogen-bond index to predict the gene-silencing efficiency of siRNA based on the local structure of mRNA [PDF]

open access: yesBiochem Biophys Res Comms, vol.320 (2) 622 (2004), 2017
The gene silencing effect of short interfering RNA (siRNA) is known to vary strongly with the targeted position of the mRNA. A number of hypotheses have been suggested to explain this phenomenon. We would like to test if this positional effect is mainly due to the secondary structure of the mRNA at the target site.
arxiv   +1 more source

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