Expression of cyclins D-type in B-chronic lymphoproliferative disorders [PDF]
Leukemia, 2000 International ...
Sola, Brigitte +6 more
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The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Unbiased Boolean analysis of public gene expression data for cell cycle gene identification. [PDF]
, 2019 Cell proliferation is essential for the development and maintenance of all organisms and is dysregulated in cancer. Using synchronized cells progressing through the cell cycle, pioneering microarray studies defined cell cycle genes based on cyclic ...
Dabydeen, Sarah A +2 more
core +1 more source
, 2012 <p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Best, A.K. +12 more
core +1 more source
The p53-MDM2 network: from oscillations to apoptosis [PDF]
, 2007 The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress.
Bose, Indrani, Ghosh, Bhaswar
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D Cyclins in CD5+ B-Cell Lymphoproliferative Disorders: Cyclin D1 and Cyclin D2 Identify Diagnostic Groups and Cyclin D1 Correlates With ZAP-70 Expression in Chronic Lymphocytic Leukemia [PDF]
American Journal of Clinical Pathology, 2006 We analyzed protein expression of cyclin D1, cyclin D2, and cyclin D3 using high-resolution enzymatic amplification staining and flow cytometry in the neoplastic cells from 80 patients with CD5+ B-cell lymphoproliferative disorders. The D cyclins were expressed differentially in chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL), and ...
Howard J, Meyerson +6 more
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BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]
, 2009 We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki +9 more
core +1 more source
CDKN1B (cyclin-dependent kinase inhibitor 1 B ) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CDKN1B (cyclin-dependent kinase inhibitor 1 B ), with data on DNA, on the protein encoded, and where the gene is implicated.
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The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. [PDF]
The EMBO Journal, 1994 We have shown previously that human cyclins A and B1 are localized differentially in the cell during interphase; cyclin A is nuclear and cyclin B1 is a cytoplasmic protein. To understand the basis of this difference we created deletion mutants and various chimeras between the two types of cyclin and expressed them in tissue culture cells by transient ...
J, Pines, T, Hunter
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