Results 191 to 200 of about 34,398 (227)

Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma

Journal of Oral Pathology & Medicine, 1999
Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in cell cycle. Aberrant exprssion of cylcin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The obective of this study was to examine cell
J, Kushner, G, Bradley, B, Young, R C, Jordan   +3 more
openaire   +2 more sources

The prognostic value of Cyclin B1 in pancreatic cancer

Medical Oncology, 2014
Pancreatic cancer (PC), a malignancy with very poor prognosis, presents many molecular alterations, including overexpression of Cyclin B1. However, the prognostic value of the protein in PC remains to be elucidated. In the present study, Cyclin B1 expression was detected immunohistochemically in specimens from 241 patients with PC and was correlated ...
Li, Zhou, Jian, Li, Yu-Pei, Zhao, Quan-Cai, Cui, Wei-Xun, Zhou, Jun-Chao, Guo, Lei, You, Wen-Ming, Wu, Tai-Ping, Zhang   +8 more
openaire   +2 more sources

Unmasking the S-Phase-Promoting Potential of Cyclin B1

Science, 2003
In higher eukaryotes, the S phase and M phase of the cell cycle are triggered by different cyclin-dependent kinases (CDKs). For example, in frog egg extracts, Cdk1–cyclin B catalyzes entry into mitosis but cannot trigger DNA replication. Two hypotheses can explain this observation: Either Cdk1–cyclin B fails to recognize the key substrates of its S ...
Jonathan D, Moore, Jane A, Kirk, Tim, Hunt   +2 more
openaire   +2 more sources

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

Nature Cell Biology, 2003
Cyclin B1-Cdk1 is the key initiator of mitosis, but when and where activation occurs has not been precisely determined in mammalian cells. Activation may occur in the nucleus or cytoplasm, as just before nuclear envelope breakdown, Polo-like kinase1 (Plk1) is proposed to phosphorylate cyclin B1 in its nuclear export sequence (NES), to trigger rapid ...
Jackman, Mark, Lindon, Catherine, Nigg, Erich A., Pines, Jonathon   +3 more
openaire   +3 more sources

Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression.

Cancer research, 2001
We have shown previously that mitotic spindle inhibitors allow the c-Myconcoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor.
X Y, Yin, L, Grove, N S, Datta, K, Katula, M W, Long, E V, Prochownik   +5 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

ABERRANT CYCLIN A AND CYCLIN B1 PROTEIN EXPRESSION IN ASTROCYTOMA

Journal of Neuropathology and Experimental Neurology, 1998
K. Allan, L. C. Ang, R. Jordan, M. Taylor, B. Young   +4 more
openaire   +1 more source

Cyclin B1

2018
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly