Results 201 to 210 of about 67,241 (220)
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Trends in Plant Science, 2018
Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter.
Arp, Schnittger, Lieven, De Veylder
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Although widely used as a marker for cell proliferation, CYCB1;1 expression is also strongly induced in cells that suffer from DNA damage. Recently, this enigmatic dual expression pattern has been resolved by proving that CYCB1;1 promotes DNA repair. This has consequences for using CYCB1;1 as a cell cycle reporter.
Arp, Schnittger, Lieven, De Veylder
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma
Medical Oncology, 2011Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli, Nar +3 more
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Overexpression of cyclin B1 in human colorectal cancers
Journal of Cancer Research and Clinical Oncology, 1997The expression of the human cyclin B1 gene was investigated with Western blot analysis in human colorectal carcinomas and in adjacent non-neoplastic colorectal mucosas. Out of 41 cancers, 36 (88% of patients) showed much higher expression of cyclin B1 than did the non-neoplastic mucosa.
A, Wang +4 more
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Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma
Journal of Oral Pathology & Medicine, 1999Cyclins play an important role in regulating the passage of dividing cells through critical checkpoints in cell cycle. Aberrant exprssion of cylcin proteins has been found in a number of human cancers, including carcinomas of the head and neck, where amplification of the cyclin D1 gene is a common finding. The obective of this study was to examine cell
J, Kushner +3 more
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The prognostic value of Cyclin B1 in pancreatic cancer
Medical Oncology, 2014Pancreatic cancer (PC), a malignancy with very poor prognosis, presents many molecular alterations, including overexpression of Cyclin B1. However, the prognostic value of the protein in PC remains to be elucidated. In the present study, Cyclin B1 expression was detected immunohistochemically in specimens from 241 patients with PC and was correlated ...
Li, Zhou +8 more
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Unmasking the S-Phase-Promoting Potential of Cyclin B1
Science, 2003In higher eukaryotes, the S phase and M phase of the cell cycle are triggered by different cyclin-dependent kinases (CDKs). For example, in frog egg extracts, Cdk1–cyclin B catalyzes entry into mitosis but cannot trigger DNA replication. Two hypotheses can explain this observation: Either Cdk1–cyclin B fails to recognize the key substrates of its S ...
Jonathan D, Moore +2 more
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Active cyclin B1–Cdk1 first appears on centrosomes in prophase
Nature Cell Biology, 2003Cyclin B1-Cdk1 is the key initiator of mitosis, but when and where activation occurs has not been precisely determined in mammalian cells. Activation may occur in the nucleus or cytoplasm, as just before nuclear envelope breakdown, Polo-like kinase1 (Plk1) is proposed to phosphorylate cyclin B1 in its nuclear export sequence (NES), to trigger rapid ...
Jackman, Mark +3 more
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Cancer research, 2001
We have shown previously that mitotic spindle inhibitors allow the c-Myconcoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor.
X Y, Yin +5 more
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We have shown previously that mitotic spindle inhibitors allow the c-Myconcoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor.
X Y, Yin +5 more
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ABERRANT CYCLIN A AND CYCLIN B1 PROTEIN EXPRESSION IN ASTROCYTOMA
Journal of Neuropathology and Experimental Neurology, 1998K. Allan +4 more
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