Results 21 to 30 of about 34,398 (227)
The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
doaj +1 more source
Biology, 2022 Cyclin-like genes are primarily considered as cell cycle regulators and have shown to be crucial for insect growth, development, reproduction, and fertility.
Muhammad Asad +5 more
doaj +1 more source
Effect of cyclins and Cdks on the cyclin B1 promoter activation [PDF]
IUBMB Life, 1997 AbstractTo study the effect of several cyclins on cyclin B1 promoter activation, we co‐transfected cyclin A, cyclin E and cyclin D1 expressing plasmids with a cyclin B1 promoter construction driving a luciferase repotnter gene into NIH 3T3 cells. All three cyclins produced activation of the reporter gene, however, co‐transfection of cyclin A with a ...
A, Moro +3 more
openaire +2 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Over‐expression of FoxM1 stimulates cyclin B1 expression [PDF]
FEBS Letters, 2001 FoxM1 (previously named WIN, HFH‐11 or Trident) is a Forkhead box (Fox) transcription factor widely expressed in proliferating cells. Various findings, including a recent analysis of FoxM1 knockout mice, suggest that FoxM1 is required for normal S–M coupling during cell cycle progression.
Tsang, ACC +8 more
openaire +4 more sources
Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol
BMC Cancer, 2008 Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Strebhardt Klaus +7 more
doaj +1 more source
Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I [PDF]
Journal of Cell Biology, 2018 Mammalian oocytes are arrested at the prophase of the first meiotic division for months and even years, depending on species. Meiotic resumption of fully grown oocytes requires activation of M-phase–promoting factor (MPF), which is composed of Cyclin B1 and cyclin-dependent kinase 1 (CDK1).
Jian Li +15 more
openaire +3 more sources
Immune Response to Cyclin B1 in Hepatocellular Carcinoma [PDF]
Hepatology, 1997 Proteins expressed by plasmids encoding human cyclins and cyclin–dependent kinase 2 (CDK2) were used as antigens in immunoblotting. Fifteen of 100 patients with hepatocellular carcinoma (HCC) were found to have autoantibodies reactive with cyclin B1 and with a 40–kd degradation product of ...
G, Covini +5 more
openaire +3 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CCNB1 (cyclin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
The International Journal of Biological Markers, 2015 Germ cell tumors (GCTs) generally express wild-type p53 protein. Rare p53 mutations may be associated with cisplatin resistance. There is growing interest in the role of cyclins as targets for GCTs.
Ugo De Giorgi MD, PhD +8 more
doaj +1 more source