Results 271 to 280 of about 152,964 (318)

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

open access: yesCell Proliferation, Volume 58, Issue 7, July 2025.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou   +5 more
wiley   +1 more source

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

open access: yesThe FEBS Journal, Volume 292, Issue 14, Page 3659-3675, July 2025.
The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura   +8 more
wiley   +1 more source

The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review. [PDF]

open access: yesAsian Pac J Cancer Prev
Romdhoni AC   +5 more
europepmc   +1 more source

Therapeutic Benefits of Topical Omega‐3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review

open access: yesJournal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.
ABSTRACT Background Oral supplementation with omega‐3 polyunsaturated fatty acids (ω‐3 PUFAs) has shown beneficial effects in some dermatologic diseases (i.e., atopic dermatitis, acne, psoriasis, burns), but the actual effect of local application of ω‐3 PUFAs for improving skin health is still under investigation.
Laura Mateu‐Arrom   +2 more
wiley   +1 more source

ESSENTIAL MEIOTIC ENDONUCLEASE 1 is required for chloroplast development and DNA repair in rice

open access: yesPlant Biotechnology Journal, Volume 23, Issue 7, Page 2931-2948, July 2025.
Summary Chloroplast development is fundamental to photosynthesis and plant growth but is sensitive to environmental stress. Chloroplast development and division require genome stability and DNA repair, but the underlying mechanisms have been unclear. Using a forward genetic approach, we identified the striped‐leaf mutant k48 in the rice (Oryza sativa L.
Yanxin Du   +5 more
wiley   +1 more source

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