Results 141 to 150 of about 622,161 (318)
Self‐assembled monolayers for perovskite solar cells
Information & Functional MaterialsIn metal‐halide perovskite solar cells (PSCs), various carrier recombination losses occur at the interface between metal oxides (MOs) and perovskite (PVK) due to the imperfect lattice structure of the crystal surface.
Dongdong Xu, Pu Wu, Hairen Tan
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Cycling in Cork City – informing policies for improvement of transport infrastructure
, 2022 Around Europe, there has been a conscientious effort on behalf of urban municipalities to expand cycling infrastructure. While these policies in favour of cycling have been established in major cities in the Netherlands since the 1970s, nascent ...
Madden, Ross
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2003 SIGLEAvailable from British Library Document Supply Centre- DSC:m03/25361 / BLDSC - British Library Document Supply CentreGBUnited ...
National Cycling Strategy Board (England) (United Kingdom)
core
Sensitivity Analysis of N2O and CH4 Emissions in a Winter Wheat–Rice Double Cropping System
AgricultureThe sensitivity of model outputs to parameter variations is crucial for effective model calibration and application. This study assessed the sensitivity of N2O and CH4 emissions to varying weather conditions and fertilization practices in a winter wheat ...
Chuang Liu +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
On the outside : constructing cycling citizenship [PDF]
, 2010 This paper uses in-depth interview data from Cambridge, England, to discuss the concept of the “cycling citizen”, exploring how, within heavily-motorised countries, the practice of cycling might affect perceptions of the self in relation to natural and ...
Aldred, Rachel
core