Results 151 to 160 of about 622,161 (318)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cycles [PDF]

EMBO reports, 2005
openaire   +2 more sources

Cycle-to-Cycle Variability

, 2013
In this chapter we shall analyze how to simulate, within a quasi-dimensional combustion model, the cyclic variability experimentally observed in spark ignition engines. Explicit qualitative comparison with experimental results will be shown. Moreover, we report a nonlinear dynamics analysis of cycle-by-cycle variations in heat release for the simulated
Alejandro Medina, Pedro Luis Curto-Risso, Antonio Calvo Hernández, Lev Guzmán-Vargas, Fernando Angulo-Brown, Asok K. Sen   +5 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship

, 2014
Background and objectiveWalking and cycling have shown beneficial effects on population risk of all-cause mortality (ACM). This paper aims to review the evidence and quantify these effects, adjusted for other physical activity (PA).Data sourcesWe ...
Thomas Götschi, Foster, C, Scarborough, Peter, Kahlmeier, Sonja, Nia Roberts, Goetschi, T, Götschi, Thomas, Paul Kelly, Scarborough, P, Orsini, Nicola, Richards, Justin, Kahlmeier, S, Richards, J, Charlie Foster, Götschi, T, Foster, Charlie, Orsini, N,, Sonja Kahlmeier, Nicola Orsini, Peter Scarborough, Roberts, N, Foster, Charles, Orsini, N, Kelly, Paul, Roberts, Nia, Justin Richards, Kelly, P   +26 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Synchronizing climate-carbon cycle heartbeats in the Phanerozoic vegetated icehouses

Nature Communications
Earth experienced state-specific climate-carbon cycle feedbacks during the Late Cenozoic Ice Age (LCIA). Whether similar feedbacks existed in the penultimate icehouse, the Late Paleozoic Ice Age (LPIA), remains uncertain.
Qiang Fang, Huaichun Wu, Isabel P. Montañez, Shu-zhong Shen, Christian Zeeden, Xiangdong Wang, Shihong Zhang, David De Vleeschouwer   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effect of the Rotor crank system on cycling performance [PDF]

, 2009
The aim of this study was to evaluate the impact of a novel crank system on laboratory time-trial cycling performance. The Rotor system makes each pedal independent from the other so that the cranks are no longer fixed at 180 degrees.
Coleman, Damian A, Galbraith, Andy, Hopker, James, Jobson, Simon A., Galbraith, Andrew, Nevill, Alan M., Coleman, Damian A., Hopker, James G.   +7 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source