Results 161 to 170 of about 622,161 (318)
Understanding urban cycling behaviours in space and time
The aim of this research thesis was to understand how the urban built environment interacts with utility cycling behaviours in space and time. Using mixed methods entrenched in the philosophy of pragmatism, the research contributed to an as yet under ...
Yeboah, Godwin
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Why a Cycling Strategy on its own will NOT Increase Cycling [PDF]
, 2003 With the recent shift in Government transport policy, more and more local councils are developing cycling strategies for their districts. However, a significant increase in cycling is not likely if such strategies are implemented in isolation from other ...
Koorey, Glen
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Campaigning for public awareness on cycling.
, 2013 In Germany experience shows that cycling campaigns have become vital and cost-effective instruments to promote cycling. Especially when they enjoy political backing, communication activities can be conducive to higher cycling levels and better valorise ...
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Base-load cycling on a system with significant wind penetration
Certain developments in the electricity sector may result in suboptimal operation of base-load generating units in countries worldwide. Despite the fact they were not designed to operate in a flexible manner, increasing penetration of variable power ...
Troy, Niamh +2 more
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Planning for cycling : principles, practice, and solutions for urban planners /
, 2002 Creating an effective policy for cycling is now an essential part of developing a sustainable transport strategy for both local and national governments. There is now a wealth of international experience of how well cycling planning works in practice and
McClintock, Hugh.
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source