Results 161 to 170 of about 141,408 (359)
Role of eIF4A1 in triple‐negative breast cancer stem‐like cell‐mediated drug resistance
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract In cap‐dependent translation, the eukaryotic translation initiation factor 4A (eIF4A1) is an mRNA helicase is involved in unwinding of the secondary structure, such as the stem‐loops, at the 5′‐leader regions of the key oncogenic mRNAs. This facilitates ribosomal scanning and translation of the oncogenic mRNAs.
Dayanidhi Raman, Amit K. Tiwari
wiley +1 more source
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. [PDF]
, 1994 Jun‐ya Kato +3 more
openalex +1 more source
Advanced Science, EarlyView.The impact of topography on the secretome of adipose‐derived stem cells (ADSCs) has the potential for promoting tendon regeneration. The secretome generated from ADSCs on aligned structure has a potent effect in promoting cell migration, proliferation, tenogenic differentiation, macrophage M2 polarization, and tendon mechanical function recovery ...
Qiuzi Long +14 more
wiley +1 more source
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background Ionizing radiation (IR) is a standard modality for the management of solid tumors. Apart from its killing effects, IR can induce pro‐survival factors leading to radioresistance of cancer. Mechanistic understanding of radiation resistance is warranted to overcome the pro‐survival effects of IR.
Seema Gupta, Mansoor M. Ahmed
wiley +1 more source
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. [PDF]
, 1992 Helena E. Richardson +4 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +8 more
wiley +1 more source
A Mathematical Model of the Cell Cycle: Exploring the Impact of Zingerone on Cancer Cell Proliferation [PDF]
arXivThis paper presents a mathematical model that explores the interactions between Cyclin-Dependent Kinase 1 (CDK1) and the Anaphase-Promoting Complex (APC) in cancer cells. Through the analysis of a dynamical system simulating the CDK1-APC network, we investigate the system's behavior and its implications for cancer progression and potential therapeutic ...
arxiv
Advanced Science, EarlyView.Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin +3 more
wiley +1 more source
Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]
arXivEffective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. [PDF]
, 1990 Pierre Pondaven +2 more
openalex +1 more source