Results 121 to 130 of about 831,285 (343)

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein [PDF]

, 2001
Zuben E. Sauna, Suresh V. Ambudkar
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A one-pot multistep cyclization yielding thiadiazoloimidazole derivatives

Beilstein Journal of Organic Chemistry, 2014
A versatile synthetic procedure is described to prepare the benzimidazole-fused 1,2,4-thiadiazoles 2a–c via a methanesulfonyl chloride initiated multistep cyclization involving the intramolecular reaction of an in-situ generated carbodiimide with a ...
Debabrata Samanta, Anup Rana, Jan W. Bats, Michael Schmittel   +3 more
doaj   +1 more source

Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids

Molecules, 2015
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris, Omar Brun, Enrique Pedroso, Anna Grandas   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Pd-Catalyzed Aromatic Dual C-H Acylations and Intramolecular Cyclization: Access to Quinoline-Substituted Hydroxyl Isoindolones

Molecules
A palladium-catalyzed aromatic dual C-H acylations followed with intramolecular cyclizations have been developed by the assistance of bidentate N-(quinolin-8-yl)benzamide.
Hongke Xu, Yuchen Yang, Fei Li, Yuzhu Yang   +3 more
doaj   +1 more source

NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest [PDF]

, 2020
Qiao Gu, Wenjie Hou, Huan Liu, Lijuan Shi, Zonghao Zhu, Wenfeng Ye, Xiaoyuan Ni   +6 more
openalex   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Solar-cycle–related Changes in the Helium Ionization Zones of the Sun [PDF]

, 2020
Courtney B. Watson, Sarbani Basu
openalex   +1 more source