Results 271 to 280 of about 831,285 (343)

Generation of Mono- and Bisazabicyclic <i>o</i>-Quinodimethanes through Polarity-Matched and -Mismatched 6π-Azaelectrocyclization: Access to Substituted Naphthalenes. [PDF]

Org Lett
Lee DJ, Shankar M, Acharya A, Giri R.
europepmc   +1 more source

Rôles et richesses des contes de randonnée en cycle 1

, 2016
Cindy Cuny
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Efficient solid-phase synthesis and structural characterization of segetalins A-H, J and K. [PDF]

Beilstein J Org Chem
Liu L, Lu W, Guo Q, Xu Z.
europepmc   +1 more source

Investigating dairy cow welfare by optimizing pulsation cycles and improving activity measurements during milking from a technical perspective

, 2016
Franziska Blümel
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Non-ribosomal peptide cyclase-directed chemoenzymatic synthesis of lariat lipopeptides. [PDF]

Nat Chem
Kobayashi M, Matsuda K, Yamada Y, Ichihara R, Onozawa N, Fukano H, Hoshino Y, Hirabayashi A, Suzuki M, Katsuyama A, Ichikawa S, Wakimoto T.   +11 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Total syntheses of highly oxidative <i>Ryania</i> diterpenoids facilitated by innovations in synthetic strategies. [PDF]

Beilstein J Org Chem
Cao ZQ, Qiao JB, Zhao YM.
europepmc   +1 more source