Results 31 to 40 of about 3,707,282 (391)

Photoredox‐Catalyzed Cyclobutane Synthesis by a Deboronative Radical Addition–Polar Cyclization Cascade

Angewandte Chemie, 2019
Photoredox‐catalyzed methylcyclobutanations of alkylboronic esters are described. The reactions proceed through single‐electron transfer induced deboronative radical addition to an electron‐deficient alkene followed by single‐electron reduction and polar
Chao Shu, Adam Noble, V. Aggarwal
semanticscholar   +1 more source

Consecutive four-component synthesis of trisubstituted 3-iodoindoles by an alkynylation–cyclization–iodination–alkylation sequence

Beilstein Journal of Organic Chemistry, 2023
A library of 19 differently substituted 3-iodoindoles is generated by a consecutive four-component reaction starting from ortho-haloanilines, terminal alkynes, N-iodosuccinimide, and alkyl halides in yields of 11–69%.
Nadia Ledermann, Alae-Eddine Moubsit, Thomas J. J. Müller   +2 more
doaj   +1 more source

Recent Advances in DMSO-Based Direct Synthesis of Heterocycles

Molecules, 2022
Besides serving as a low-toxicity, inexpensive and easily accessible solvent, dimethyl sulfoxide (DMSO) has also been extensively used as a versatile reagent for the synthesis of functionalized molecules.
Hai-Lei Cui
doaj   +1 more source

Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones [PDF]

, 2009
A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively.
Bernardini, Martina, Botta, Maurizio, Castagnolo, Daniele, Pagano, Mafalda   +3 more
core   +1 more source

Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain

Frontiers in Chemistry, 2015
Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function.
Frank H Schumann, Ranjani eVaradan, Praveen Pudiavettil Tayakuniyil, Jennifer Hall Grossman, Julio A Camarero, Julio A Camarero, David eFushman   +6 more
doaj   +1 more source

Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

Pharmaceuticals, 2021
This review concerns the synthesis and biological activities of pyrazino[1,2-a]indoles and pyrazino[1,2-a]indol-1-ones reported since 1997 and the discovery of biological activity of pyrazinoindole derivatives.
Kena Zhang, Christine Tran, Mouad Alami, Abdallah Hamze, Olivier Provot   +4 more
doaj   +1 more source

Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids [PDF]

, 2012
A base-mediated 6-endo-trig cyclization of readily accessible enone-derived α-amino acids has been developed for the direct synthesis of novel 2,6-cis-6- substituted-4-oxo-L-pipecolic acids. A range of aliphatic and aryl side chains were tolerated by
Agami C., Alastair A. Cant, Andrew Sutherland, Bernasconi R., Boger D. L., Cant A. A., Carbonnel S., Fowler L. S., Fowler L. S., Golubev A., Graham L. Simpson, Gutiérrez M. C., Hans Martin Senn, He M., Ireland R. E., Jatoi W. B., Johnson F., Jung J.-C., Kadouri-Puchot C., Lamarre D., Lindsay S. Fowler, Marin J., Mark Daly, Merino P., Occhiato E. G., Occhiato E. G., Purkayastha N., Purkayastha N., Romeo J. T., Romo D., Rudisill D. E., Schenk V. W., Smith A. B., Smith A. B., Smith A. B., Swindells D. C., Tanaka H., Vanderhaeghe H., Weigend F., Zacharius R. M., Zhao Y., Zhao Y.   +41 more
core   +1 more source

Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties

Beilstein Journal of Organic Chemistry, 2017
Intramolecular nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole esters is described. Efficient routes towards the synthesis of pyrrolopyrazinone, pyrrolotriazinone and pyrrolooxazinone have been developed.
Işıl Yenice, Sinan Basceken, Metin Balci   +2 more
doaj   +1 more source

Study on by-products synthesis of powder coating polyester resin catalyzed by organotin

e-Polymers, 2023
In the production of powder-coating polyester, a strong odor emanates from the water, prompting us to investigate its composition and origin. We studied the process of powder coating epoxy/polyester 50/50, which employs butyl tin tris (2-ethyl hexanoate)
Yang YuCheng, Di Chao, Wang TingWei
doaj   +1 more source

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources