Molecules, 2020 Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated.
Biligma Tsyrenova, Valentine Nenajdenko
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Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones [PDF]
, 2019 We report a catalytic asymmetric Nazarov cyclization of simple, acylic, alkyl-substituted divinyl ketones using our recently disclosed strong and confined imidodiphosphorimidate Brønsted acids.
De, C. +4 more
core +2 more sources
Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals
Nature Chemistry, 2017 The rapid generation of molecular complexity from simple starting materials is a key challenge in synthesis. Enantioselective radical cyclization cascades have the potential to deliver complex, densely packed, polycyclic architectures, with control of three-dimensional shape, in one step.
Nicolas Kern +3 more
openaire +5 more sources
Confinement and Viscoelastic effects on Chain Closure Dynamics
, 2012 Chemical reactions inside cells are typically subject to the effects both of the cell's confining surfaces and of the viscoelastic behavior of its contents.
Binny J. Cherayil +7 more
core +1 more source
Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids [PDF]
, 2012 A base-mediated 6-endo-trig cyclization of readily accessible enone-derived α-amino acids has been developed for the direct synthesis of novel 2,6-cis-6- substituted-4-oxo-L-pipecolic acids. A range of aliphatic and aryl side chains were tolerated by
Agami C. +41 more
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Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. [PDF]
, 2015 A unified strategy for enantioselective total synthesis of all stereoisomers of the 2+2 family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursors ...
Canham, Stephen M +6 more
core +4 more sources
Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
Frontiers in Chemistry, 2019 The renaissance of peptides as prospective therapeutics has fostered the development of novel strategies for their synthesis and modification. In this context, besides the development of new chemical peptide ligation approaches, especially the use of ...
Timo Nuijens +5 more
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Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations
Frontiers in Chemistry, 2022 N-heterocycles are key structural units in many drugs, biologically interesting molecules and functional materials. To avoid the residues of metal catalysts, the construction of N-heterocycles under metal-free conditions has attracted much research ...
Huiqiao Wang +4 more
doaj +1 more source
Mechanism, reactivity, and selectivity of nickel-catalyzed [4 + 4 + 2] cycloadditions of dienes and alkynes. [PDF]
, 2014 Density functional theory (DFT) calculations with B3LYP and M06 functionals elucidated the reactivities of alkynes and Z/E selectivity of cyclodecatriene products in the Ni-catalyzed [4 + 4 + 2] cycloadditions of dienes and alkynes.
Baran, Phil S +4 more
core +2 more sources
Population Ecology, EarlyView.This study examines the demographic dynamics of two seabird populations on Tromelin Island, 15 years after the eradication of brown rats. The results indicate that these populations are in good health and are expected to continue growing until breeding sites are saturated in about a century.
Merlène Saunier +6 more
wiley +1 more source