Results 31 to 40 of about 164,620 (294)

Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters

Frontiers in Chemistry, 2021
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan, Anna Meschkov, Anna Meschkov, Ute Schepers, Ute Schepers, Stefan Bräse, Stefan Bräse   +6 more
doaj   +1 more source

Enzymatic Bromocyclization of α‐ and γ‐Allenols by Chloroperoxidase from Curvularia inaequalis

ChemistryOpen, 2022
Vanadate‐dependent chloroperoxidase from Curvularia inaequalis catalyzes 5‐endo‐trig bromocyclizations of α‐allenols to produce valuable halofunctionalized furans as versatile synthetic building blocks. In contrast to other haloperoxidases, also the more
Janne M. Naapuri, Philip K. Wagner, Prof. Dr. Frank Hollmann, Prof. Dr. Jan Deska   +3 more
doaj   +1 more source

Asymmetric dearomatization/cyclization enables access to polycyclic chemotypes [PDF]

, 2016
Enantioenriched, polycyclic compounds were obtained from a simple acylphloroglucinol scaffold. Highly enantioselective dearomatization was accomplished using a Trost ligand-palladium(0) complex.
Boyce, Burke, Butts, Choi, Ciochina, George, Hayes, Horeischi, Hurtley, Karkas, Keith, Lu, Mitasev, Richard, Schreiber, Simpkins, Singh, Sparling, Spessard, Trabocchi, Trost, Trost, Trost, Trost, Uwamori, Weedon, Xuan, Zhang, Zhang, Zhu, Zhuo   +30 more
core   +1 more source

Computational Investigation of Mechanism and Selectivity in (3+2) Cycloaddition Reactions Involving Azaoxyallyl Cations

Reactions
Azaoxyallyl cations, as novel and versatile three-atom components, have been widely utilized in cycloaddition reactions, with the competition between O- and N-cyclization pathways remaining a key research focus.
Wei Zhou, Lei Zhang, Guixian Liu, Xiaosi Ma, Xiangtai Meng   +4 more
doaj   +1 more source

Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes

Biomolecules, 2020
Structurally diverse carbazole alkaloids are valuable due to their pharmaceutical properties and have been isolated from nature. Experimental knowledge on carbazole biosynthesis is limited. The latest development of in silico analysis of the biosynthetic
Masaya Kobayashi, Tomohisa Kuzuyama
doaj   +1 more source

Neutral and Cationic Rare Earth Metal Alkyl and Benzyl Compounds with the 1,4,6-Trimethyl-6-pyrrolidin-1-yl-1,4-diazepane Ligand and Their Performance in the Catalytic Hydroamination/Cyclization of Aminoalkenes [PDF]

, 2008
A new neutral tridentate 1,4,6-trimethyl-6-pyrrolidin-1-yl-1,4-diazepane (L) was prepared. Reacting L with trialkyls M(CH2SiMe3)3(THF)2 (M = Sc, Y) and tribenzyls M(CH2Ph)3(THF)3 (M = Sc, La) yielded trialkyl complexes (L)M(CH2SiMe3)3 (M = Sc, 1; M = Y ...
Arndt S., Arndt S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Booij M., Carver C. T., De Kimpe N., Douglass M. R., Douglass M. R., Evans W. J., Gagné M. R., Gagné M. R., Gao W., Ge S, Ge S., Ge S., Ge S., Giardello M. A., Gribkov D. V., Hajela S., Hayes P. G., Hong S, Horino Y., Howe R. G., Kawaoka A. M., Kim J. Y., Komeyama K., Lappert M. F., Lauterwasser F., Lawrence S. C., Li W., Liu Y., Lukesova L., Lukesova L., Meyer N., Meyer N., Molander G. A., Molander G. A., Nishiura M., Robert D., Ryu J. -S, Sakakura Y., Shannon R. D., Stubbert B. D., Tardif O., Tazelaar C. G. J., Tokuda M., Tredget C. S., Trifonov A. A, Wang Q., Ward B. D., Yu P. F., Yuen H. F., Zeimentz P. M., Zhang L.   +60 more
core   +3 more sources

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes

Molecules, 2023
Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes.
Yun-Tao Xia, Ya-Xin Li, Tong-Tong Bi, Wei Lian, Xia Wang, Meng Yan, Tao Guo   +6 more
doaj   +1 more source

Free radical cyclizations [PDF]

Pure and Applied Chemistry, 1967
Abstract
openaire   +1 more source

The Effects of Stacking on the Configurations and Elasticity of Single Stranded Nucleic Acids [PDF]

, 2004
Stacking interactions in single stranded nucleic acids give rise to configurations of an annealed rod-coil multiblock copolymer. Theoretical analysis identifies the resulting signatures for long homopolynucleotides: A non monotonous dependence of size on
A. Buhot, A. Halperin, C. R. Cantor, F. J. Bollum, M. Doi, P. G. de Gennes, T. Godefroy-Colburn, T. M. Birshtein, V. A. Bloomfield   +8 more
core   +1 more source