Results 101 to 110 of about 82,507 (282)

Total Synthesis of Proteasome Inhibitor (−)-Omuralide through Asymmetric Ketene [2 + 2]-Cycloaddition

, 2018
The total synthesis of (−)-omuralide, a potent specific proteasome inhibitor, has been achieved through an unprecedented route. The C3 and C4 chiral centers of the natural product have been selectively installed by an asymmetric [2 + 2]-cycloaddition ...
Cannillo, Alexandre, Grisel, Julien, Sébastien Carret (1825888), Pauline Rullière (2627395), Cividino, Pascale, Jean-François Poisson (1696750), Rullière, Pauline, Julien Grisel (2809129), Alexandre Cannillo (1590250), Pascale Cividino (1696738), Poisson, Jean-François, Carret, Sébastien   +11 more
core   +1 more source

[2 + 2] Cycloaddition of Ynamides to Construct 3‑Aminocyclobutenones

, 2022
An efficient Tf2NH-catalyzed [2 + 2] cycloaddition of ynamides under mild conditions has been developed. Within short reaction times, various ynamides are transformed into the corresponding 3-aminocyclobutenones in good to excellent yields.
Xiao-Na Wang (289380), Lixia Ding (1517029), Mengjun Hu (11895746), Yanan Wang (123548), Junbiao Chang (1523644), Yanru Wang (187231)   +5 more
core   +1 more source

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source

Computational and Spectral Investigation of 5,12-Dihydro-5,12-ethanonaphthacene-13-carbaldehyde

Molecules, 2011
A conformational search of 5,12-dihydro-5,12-ethanonaphthacene-13-carbaldehyde predicted the presence of twelve conformations. The geometry of the twelve conformations established at the B3LYP/6-31G* level showed only six unique ones.
Abdulrahman I. Almansour, Adel A. El-Azhary, Usama Karama, Mohammed H. Jaafar, Turki M. Al-Turki, Abdulla A. Al-Kahtani   +5 more
doaj   +1 more source

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

cycloaddition

, 2014
Citation: 'cycloaddition' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C01496 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial
openaire   +2 more sources

Reactions of Cyclopentadienyl-Amidinate Titanium Hydrazides with CO2, CS2, and Isocyanates: Ti=N-alpha Cycloaddition, Cycloaddition-Insertion, and Cycloaddition-NNR2 Group Transfer Reactions

, 2011
We report a comprehensive combined experimental and DFT investigation of the synthesis, molecular and electronic structures, and reactivity of terminal hydrazido complexes with CO2, CS2, isocyanates, and isothiocyanates.
Schwarz, AD, Tiong, PJ, Nova, A, Clot, E, Groom, LR, Schofield, AD, Mountford, Philip, Selby, JD, Schofield, A. Daniel, Nova-Flores, Ainara, Clot, Eric, A. Daniel Schofield, Selby, Jonathan,, Schwarz, Andrew,, Andrew D. Schwarz, Schwarz, Andrew, D., Ainara Nova, Jonathan D. Selby, Pei Jen Tiong, Selby, Jonathan, D., Laura R. Groom, Groom, Laura R., Tiong, Pei-Jen, Eric Clot, Philip Mountford   +24 more
core   +2 more sources

Deal;Photoredox Catalysis for the Cycloaddition Reactions

, 2020
: Cycloaddition reaction is a powerful tool for the synthesis of cyclic structures in a green way. High-energy ultraviolet (UV) light was strictly required for the traditional photochemical processes.
Shoubhik Das, Das, Shoubhik, Zhang, Yu, Tong Zhang, Yu Zhang, Zhang, Tong   +5 more
core   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Cycloadditions as a Sweet Route to ‘Double C-Glycosylation’

Biomolecules
Pharmaceuticals, such as the antibiotic erythromycin, and sodium-dependent glucose transporter (SGLT1 & SGTL2) inhibitors such as Bexagliflozin (diabetes) and Sotagliflozin (heart disease), are often sugar-decorated (glycosylated). Glycosylation is a key
Kevin P. P. Mahoney, Rosemary Lynch, Rhea T. Bown, Sunil V. Sharma, Piyasiri Chueakwon, G. Richard Stephenson, David B. Cordes, Alexandra M. Z. Slawin, Rebecca J. M. Goss   +8 more
doaj   +1 more source