Results 121 to 130 of about 82,507 (282)
Inorganics, 2019 [2 + 2 + 2] cycloaddition of a 1,2-bis(propiolyl)benzene derivative with terminal and internal alkynes takes place in the presence of [Ir(cod)Cl]2 (cod = 1,5-cyclooctadiene) combined with bis(diphenylphosphino)ethane (DPPE) to give anthraquinones in 42 ...
Takahiro Sawano +2 more
doaj +1 more source
Advanced Science, EarlyView.We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong +11 more
wiley +1 more source
Synthesis of Different Heterocyclic Compounds of Pharmaceutical Relevance [PDF]
This thesis describes the synthesis of different cyclic imines and the exploration of their reactivity with cyclopropenones and 1,3-dipoles,as well as an investigation of the chemistry of the products.
Khan, Musharraf Naveed
core +2 more sources
Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs
Beilstein Journal of Organic Chemistry, 2019 The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β ...
Juanjuan Feng +3 more
doaj +1 more source
Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions
Advanced Science, EarlyView.This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing
Advanced Science, EarlyView.A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi +8 more
wiley +1 more source
Catalytic cycloaddition of acrylates to norbornadiene. Kinetics and mechanism
Тонкие химические технологии, 2010 Kinetics of [2+2+2]-cycloaddition of acrylates to norbornadiene in the presence of η3-bis(allyl) nickel was studied. The thermodynamic parameters were determined. Kinetics equations for all of the isomer reaction products were found.
I. E. Efros +3 more
doaj
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Cycloaddition of oxidopyrylium species in organic synthesis
, 2008 In the current survey, to highlight the cycloaddition of oxidopyrylium ylides and their application in organic synthesis. Cycloaddition of the related carbonyl ylides, generated by rhodium-catalyzed addition of diazo ketones, has recently been reviewed ...
SINGH, VISHWAKARMA +3 more
core +1 more source