Results 141 to 150 of about 82,507 (282)
Active Metal Template Synthesis of Rotaxanes From BINOL‐Phosphate Macrocycles
Angewandte Chemie, EarlyView.The use of macrocyclic BINOL‐phosphates allows for the active metal template synthesis of [2]rotaxanes via Cu(I)‐mediated alkyne‐azide cycloaddition. DFT calculations, control experiments, and kinetic experiments support a dinuclear phosphate‐Cu2 intermediate.
Nikolai Brodt +10 more
wiley +2 more sources
Advanced Science, EarlyView.X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li +7 more
wiley +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Heavy‐Atom Tunneling at Room Temperature Revealed by Instanton Theory
Angewandte Chemie, EarlyView.Usually, tunneling does not play a significant role in chemical reactions except at low temperature, especially when heavy atoms are involved. However, using nonadiabatic instanton theory we find that heavy‐atom tunneling dominates the reaction mechanism for spin‐forbidden processes in the synthesis of strained organic molecules even at room ...
Debaarjun Mukherjee +2 more
wiley +2 more sources
Cycloaddition of Diphenylnitrilimine to 1,5-Benzodiazepines [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 The cycloaddition reaction of diphenylnitrilimine on the 1,5-benzodiazepines has been studied. New molecules of triazolobenzodiazepines type have been isolated and characterized.
Rachid Zinber +4 more
doaj
A Simple and Highly Efficient Iron Catalyst for a [2 + 2 + 2] Cycloaddition to Form Pyridines
, 2011 A Simple and Highly Efficient Iron Catalyst for a [2 + 2 + 2] Cycloaddition to Form ...
王春翔, 吴凡, 万伯顺, 李新成
core
Enzyme‐Linked Cycloaddition Assay (ELCA) for Rapid, Ultra‐Sensitive Monitoring of Secreted Sialoglycoproteins [PDF]
Advanced scienceSecreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Lundstrøm J, Yang J, Bojar D.
europepmc +2 more sources
Iron-Catalyzed Cycloaddition Reaction of Diynes and Cyanamides at Room Temperature
, 2013 An iron-catalyzed [2 + 2 + 2] cycloaddition reaction of diynes and cyanamides at room temperature is reported. Highly substituted 2-aminopyridines were obtained in good to excellent yields with high regioselectivity.
Wan, Boshun +5 more
core +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
MoleculesThe molecular mechanism of the reaction between 2-methoxyfuran and ethyl (Z)-3-phenyl-2-nitroprop-2-enoate was investigated using wb97xd/6-311+G(d,p)(PCM) quantum chemical calculations.
Mikołaj Sadowski +3 more
doaj +1 more source