Results 101 to 110 of about 73,410 (278)

Synthesis of Benzofuro[3,2-b]indol-3-one Derivatives via Dearomative (3 + 2) Cycloaddition of 2-Nitrobenzofurans and para-Quinamines

Molecules
An efficient dearomative (3 + 2) cycloaddition of para-quinamines and 2-nitrobenzofurans has been developed. This reaction proceeds smoothly under mild conditions and affords a series of benzofuro[3,2-b]indol-3-one derivatives in good to excellent yields
Wei-Cheng Yuan, Hai-Ying Zeng, Yan-Ping Zhang, Jian-Qiang Zhao, Yong You, Jun-Qing Yin, Ming-Qiang Zhou, Zhen-Hua Wang   +7 more
doaj   +1 more source

Vinylene-Linked Covalent Organic Frameworks by Base-Catalyzed Aldol Condensation [PDF]

, 2019
Two 2D covalent organic frameworks (COFs) linked by vinylene (−CH=CH−) groups (V‐COF‐1 and V‐COF‐2) are synthesized by exploiting the electron deficient nature of the aromatic s‐triazine unit of C3‐symmetric 2,4,6‐trimethyl‐s‐triazine (TMT).
Acharjya, Amitava, Pachfule, Pradip, Roeser, Jérôme, Schmitt, Franz-Josef, Thomas, Arne   +4 more
core   +1 more source

Asymmetric formal [1 + 2 + 2]-cycloaddition of diazoamides with enamines and carbonyl compounds

Nature Communications
Cycloaddition reaction offers an ideal and powerful method for the construction of cyclic structures with molecular complexity and diversity.
Shanliang Dong, Minghan Yao, Yunzhe Wang, Xiongda Xie, Xinyu Jiang, Xinfang Xu   +5 more
doaj   +1 more source

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

Beilstein Journal of Organic Chemistry, 2016
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis.
Manjunatha Narayanarao, Lokesh Koodlur, Vijayakumar G. Revanasiddappa, Subramanya Gopal, Susmita Kamila   +4 more
doaj   +1 more source

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. [PDF]

, 2020
In vivo compatible reactions have a broad range of possible applications in chemical biology and the pharmaceutical sciences. Here we report tetrazines that can be removed by exposure to isonitriles under very mild conditions.
Eckvahl, Hannah J, Franzini, Raphael M, Houk, KN, Parvez, Saba, Peterson, Randall T, Svatunek, Dennis, Tu, Julian, Xu, Minghao   +7 more
core  

Continual reproduction of self-assembling oligotriazole peptide nanomaterials. [PDF]

, 2017
Autocatalytic chemical reactions, whereby a molecule is able to catalyze its own formation from a set of precursors, mimic nature's ability to generate identical copies of relevant biomolecules, and are thought to have been crucial for the origin of life.
Brea, Roberto J, Devaraj, Neal K
core   +2 more sources

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation

Beilstein Journal of Organic Chemistry, 2016
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with ...
Xiaofeng Zhang, Kenny Pham, Shuai Liu, Marc Legris, Alex Muthengi, Jerry P. Jasinski, Wei Zhang   +6 more
doaj   +1 more source

The alpha-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations [PDF]

, 2009
Five-membered secondary amine heterocycles containing an α-heteroatom were prepared and shown to be ineffective as catalysts for the iminium ion catalysed Diels–Alder reaction between cinnamaldehyde and cyclopentadiene.
Cavill, Julie L., Elliott, Richard L., Evans, Gareth, Gibbs, Timothy J. K., Jones, Ian L., Platts, James A, Porzelle, Achim, Tomkinson, Nick   +7 more
core   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

The Search for an Epoxide Precursor in Trimethylenemethane (TMM) Cycloaddition Reactions [PDF]

, 2012
Trimethylenemethane (TMM) cycloaddition is a Pd(0)-catalyzed process in which new carbon rings are formed, which can be potentially useful in synthetic organic processes.
Miko, Christopher
core   +2 more sources