Results 111 to 120 of about 2,202,700 (266)

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones

Advanced Science, EarlyView.
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Yi‐Lin Zhao, Bei‐Bei Zhang, Xueying Guo, Kui Dong, Zhi‐Xiang Wang, Li‐Zhu Wu, Qiang Liu   +6 more
wiley   +1 more source

Chemo- and Regioselective 1,3-Dipolar Cycloaddition of Nitrile Imines to 5-Arylmethylene-2-methylthiohydantoins

Organics
1,3-Dipolar cycloaddition reactions of nitrile imines are a powerful tool for the construction of spirocyclic frameworks, yet controlling chemoselectivity remains challenging when dipolarophiles contain multiple reactive sites.
Maria E. Filkina, Lev A. Lintsov, Victor A. Tafeenko, Maxim E. Kukushkin, Elena K. Beloglazkina   +4 more
doaj   +1 more source

From Mechanistic Study to Chiral Catalyst Optimization: Theoretical Insight into Binaphthophosphepine-catalyzed Asymmetric Intramolecular [3 + 2] Cycloaddition

Scientific Reports, 2017
Density functional M11 was used to study the mechanism and enantioselectivity of a binaphthophosphepine-catalyzed intramolecular [3 + 2] cycloaddition reaction.
Meng Duan, Lei Zhu, Xiaotian Qi, Zhaoyuan Yu, Yingzi Li, Ruopeng Bai, Yu Lan   +6 more
doaj   +1 more source

PHOTOCHEMICAL-REACTION OF CHROMIUM-CARBENE COMPLEXES WITH OLEFINS AND DIENES - A COMPARISON WITH THE [2+2]-CYCLOADDITION OF KETENES

, 1992
KOBBING S, Mattay J. PHOTOCHEMICAL-REACTION OF CHROMIUM-CARBENE COMPLEXES WITH OLEFINS AND DIENES - A COMPARISON WITH THE [2+2]-CYCLOADDITION OF KETENES. Tetrahedron Letters. 1992;33(7):927-930.Described is the preparation of cyclobutanones via the [2+2]-
Mattay, Jochen, Jochen Mattay, Stephan Köbbing, KOBBING, S   +3 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Topology‐Driven X‐Shaped DNA as a cGAS Stimulator to Promote Dendritic Cell Activation and Antitumor Vaccine Efficacy

Advanced Science, EarlyView.
X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li, Xuan Wang, Dali Wei, Zhejie Chen, Ziyi Wang, Qing Yu, Yu Yang, Shengpeng Wang   +7 more
wiley   +1 more source

Active Metal Template Synthesis of Rotaxanes From BINOL‐Phosphate Macrocycles

Angewandte Chemie, EarlyView.
The use of macrocyclic BINOL‐phosphates allows for the active metal template synthesis of [2]rotaxanes via Cu(I)‐mediated alkyne‐azide cycloaddition. DFT calculations, control experiments, and kinetic experiments support a dinuclear phosphate‐Cu2 intermediate.
Nikolai Brodt, Sophia Stadtfeld, Somayyeh Kheirjou, Tibor Schumski, Adrian M. Bialowons, Dennis Jansen, Felix Niemeyer, Torsten Schaller, Gebhard Haberhauer, Jan Riebe, Jochen Niemeyer   +10 more
wiley   +2 more sources

A Molecular Electron Density Theory Study of the Domino [4+2]/[3+2] Cycloaddition Leading to a Tricyclic 1,2-Oxazine Nitrones

Molecules
The reaction of 2,5-dimethylfuran (DMF) with two equivalents of α-nitrosostyrene (NS) leading to a tricyclic 1,2-oxazine nitrone (TON) has been examined theoretically at the ωB97X-D/6-311G(d,p) computational level. In this case, the domino process should
Agnieszka Kącka-Zych, Luis R. Domingo
doaj   +1 more source

Web Table 1. Free energy profile of the uncatalysed model π2s+π4s cycloaddition reaction

, 2013
Web Table 1.
Steven Lal (463738), Silvia Diez (437790), Henry S. Rzepa (96582)   +2 more
core   +1 more source