Results 121 to 130 of about 44,314 (270)
Angewandte Chemie, EarlyView.Azidoborylene photolysis results in the isolation of a reactive C═B═N═C heterocumulene bearing an ambiphilic boron centre. Addition of 3O2 to this species results in the clean conversion to a unique example of a dioxaborirane. ABSTRACT Oxidation of the formal boron(0) complex MeCAAC2B in the presence of tetrabutylammonium azide leads to the formation ...
Hayley King +4 more
wiley +2 more sources
Thiourea-catalyzed Diels–Alder reaction of a naphthoquinone monoketal dienophile
Beilstein Journal of Organic Chemistry, 2013 A variety of organocatalysts were screened for the catalysis of the naphthoquinone monoketal Diels–Alder reaction. In this study we found that Schreiner's thiourea catalyst 10 and Jacobson's thiourea catalyst 12 facilitate the cycloaddition of the ...
Carsten S. Kramer, Stefan Bräse
doaj +1 more source
Angewandte Chemie, EarlyView.Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa +4 more
wiley +2 more sources
The Reactivity of Addends in the 1,3-Dipolar Cycloaddition Reaction
, 2020 The influence of donor-acceptor interactions and localisation energies on the reactivity of addends in the 1,3-dipolar cycloaddition reaction is examined.
Samuilov Y., Konovalov A.
core
Cycloaddition Reaction of Methyl Coumalate with Fulvenes [PDF]
, 1983 Cycloaddition reaction of methyl 2-pyrone-5-carboxylate to dimethyl- and phenyl- fulvene gave peri-, regio, and stereoselectively l -isopropylidene- and l -benzylidene-6-methoxycarbonyl-r-3a, 4, 7, c-7a-tetrahydroindene-c-4, c-7-carbolactone ...
IMAGAWA, Takeshi
core
Angewandte Chemie, EarlyView.The excited‐state antiaromaticity of hydroxybenzotropyliums (HBTs) can be tuned through substituent effects to bring the aromatic ‘enol’ (E) and keto (K) tautomers close in energy. This leads to abnormally slow excited‐state proton transfer (on the ns timescale), giving rise to dual fluorescence emission and weak photoacidity.
Promeet K. Saha +6 more
wiley +2 more sources
Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation
Angewandte Chemie, EarlyView.The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu +12 more
wiley +2 more sources
Autocatalytic Cycles in a Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction
, 2018 This work describes the autocatalytic copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction between tripropargylamine and 2-azidoethanol in the presence of Cu(II) salts.
Anastasiia M. Finogenova (4354735) +15 more
core +2 more sources
Síntese de derivados heterocíclicos com potencial atividade antitripanossomatídeos [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.Os fármacos utilizados nos tratamentos atuais de tripanossomatídeos, Trypanosoma cruzi (doença de ...
Zimmermann, Lara Almida
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Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources