Results 61 to 70 of about 44,314 (270)

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

[6 + 2] AND [4 + 2] CYCLOADDITION REACTION OF DIPHENYLKETENE AND CYCLOHEPTATRIENE [PDF]

Journal of Sciences, Islamic Republic of Iran, 1993
The cycloaddition reaction of diphenylketene and cycloheptatriene is studied. The reaction proceeds via a highly asynchronous reaction path to the zwitterionic 6 as intermediate. Subsequent CC- bond formation yields 8, 8 diphenylbicyclo [4. 2. I] nona-2,
doaj  

Ultrasound-promoted synthesis of novel fused heterocycles by criss-cross cycloaddition

Journal of Saudi Chemical Society, 2016
This work reports a novel and highly efficient methodology for the synthesis of perhydrotriazolotriazoledithions from two successive 1,3-dipolar cycloaddition under ultrasound irradiation.
Javad Safari, Soheila Gandomi-Ravandi, Marzieh Ghotbinejad   +2 more
doaj   +1 more source

Recent advances in the iron-catalyzed cycloaddition reactions

, 2012
The rapid generation of molecular in a relatively easy manner has made the cycloaddition reaction a powerful tool in the synthesis of different membered ring compounds.
Wang ChunXiang, Wan BoShun, 万伯顺
core   +1 more source

Asymmetric isothiourea-catalysed formal [3+2] cycloadditions of ammonium enolates with oxaziridines [PDF]

, 2015
The authors thank the Royal Society for a University Research Fellowship (A.D.S.) and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007—2013), ERC Grant Agreement No. 279850 (C.F.
McLennan, Ross, Taylor, James E., Taylor, James Edward, McLennan, Ross Sinclair, Smith, Siobhan R., Morrill, Louis Christian, Daniels, David Sydney Bernard, Smith, Siobhan Rose, Slawin, Alexandra Martha Zoya, Morrill, Louis C., Smith, Andrew D., Daniels, David S. B., Fallan, Charlene, Smith, Andrew David, Slawin, Alexandra M. Z.   +14 more
core   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

MOF-Derived Cu@Cu2O Nanocatalyst for Oxygen Reduction Reaction and Cycloaddition Reaction

Nanomaterials, 2018
Research on the synthesis of nanomaterials using metal-organic frameworks (MOFs), which are characterized by multi-functionality and porosity, as precursors have been accomplished through various synthetic approaches.
Aram Kim, Nallal Muthuchamy, Chohye Yoon, Sang Hoon Joo, Kang Hyun Park   +4 more
doaj   +1 more source

Cycloaddition reactions of enoldiazo compounds [PDF]

Chemical Society Reviews, 2017
A comprehensive review on cycloaddition reactions of enoldiazo compounds is presented with emphasis on methodology development and mechanistic insight.
Qing-Qing Cheng, Yongming Deng, Marianne Lankelma, Michael P. Doyle   +3 more
openaire   +2 more sources