Results 61 to 70 of about 2,089,289 (186)

Multicomponent Hetero-[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery

, 2016
Multicomponent reactions (MCR), transformations employing three or more simple substrates in a single and highly atom-economical operation, are very attractive in both natural product synthesis and diversity-oriented synthesis of druglike molecules ...
Hall, Dennis G., Verdelet, Tristan, Rybak, Taras   +2 more
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Synthesis of Functionalized 3‑Spiro[cyclopropa[a]pyrrolizine]- and 3‑Spiro[3-azabicyclo[3.1.0]hexane]oxindoles from Cyclopropenes and Azomethine Ylides via [3 + 2]-Cycloaddition

, 2017
3-Spiro­[cyclopropa­[a]­pyrrolizine]- and 3-spiro­[3-aza­bicyclo­[3.1.0]­hexane]­oxindoles were prepared in moderate to high yields via one-pot three-component reactions using substituted isatins, α-amino acids, and cyclopropenes.
Alexander V. Stepakov (3610274), Alexander P. Molchanov (2121553), Alexander S. Filatov (1678900), Rafael R. Kostikov (2447929), Taras L. Panikorovsky (3610265), Vitali M. Boitsov (3610268), Anna G. Larina (3610262), Nickolay A. Knyazev (3610271)   +7 more
core   +1 more source

Synthesis of Benzofuro[3,2-b]indol-3-one Derivatives via Dearomative (3 + 2) Cycloaddition of 2-Nitrobenzofurans and para-Quinamines

Molecules
An efficient dearomative (3 + 2) cycloaddition of para-quinamines and 2-nitrobenzofurans has been developed. This reaction proceeds smoothly under mild conditions and affords a series of benzofuro[3,2-b]indol-3-one derivatives in good to excellent yields
Wei-Cheng Yuan, Hai-Ying Zeng, Yan-Ping Zhang, Jian-Qiang Zhao, Yong You, Jun-Qing Yin, Ming-Qiang Zhou, Zhen-Hua Wang   +7 more
doaj   +1 more source

Asymmetric formal [1 + 2 + 2]-cycloaddition of diazoamides with enamines and carbonyl compounds

Nature Communications
Cycloaddition reaction offers an ideal and powerful method for the construction of cyclic structures with molecular complexity and diversity.
Shanliang Dong, Minghan Yao, Yunzhe Wang, Xiongda Xie, Xinyu Jiang, Xinfang Xu   +5 more
doaj   +1 more source

Calculated activation and reaction energies for the cycloaddition reactions.

, 2015
Calculated activation and reaction energies (B3LYP/6-311+G(d) level, kcal/mol) for the cycloaddition reactions (see Fig. 2).Calculated activation and reaction energies for the cycloaddition reactions.
Valentine P. Ananikov (718886), Evgeniy G. Gordeev (718885)   +1 more
core   +1 more source

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

Beilstein Journal of Organic Chemistry, 2016
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis.
Manjunatha Narayanarao, Lokesh Koodlur, Vijayakumar G. Revanasiddappa, Subramanya Gopal, Susmita Kamila   +4 more
doaj   +1 more source

New catalytic strategies for DNA and RNA alkylation using rhodium (II) and copper (I) carbenes - a versatile tool for applications in chemical biology [PDF]

, 2015
A variety of nucleic acid substrates were catalytically alkylated with rhodium(II) and copper(I)-carbenoids generated from diazocarbonyl compounds. The alkylation took place via an N-H insertion reaction selectively targeting the nucleobases in single ...
Tishinov, Kiril
core   +1 more source

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation

Beilstein Journal of Organic Chemistry, 2016
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with ...
Xiaofeng Zhang, Kenny Pham, Shuai Liu, Marc Legris, Alex Muthengi, Jerry P. Jasinski, Wei Zhang   +6 more
doaj   +1 more source

Síntese de derivados heterocíclicos com potencial atividade antitripanossomatídeos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.Os fármacos utilizados nos tratamentos atuais de tripanossomatídeos, Trypanosoma cruzi (doença de ...
Zimmermann, Lara Almida
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Azide-alkyne cycloaddition reaction in ionic liquids

, 2022
Azīda-alkīna ciklopievienošanās reakcija jonu šķidrumos. Sloboda D., zinātniskais vadītājs Dr.Chem. Baķis E., Maģistra darbs, 83 lappuses, 54 attēli, 5 tabulas, 44 literatūras avoti, 6 pielikumi. Latviešu valodā. Maģistra darba ietvaros sintezēja dažādu
Sloboda, Diāna
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