Results 41 to 50 of about 2,202,700 (266)

Intramolecular Imino Diels-Alder Reaction: Progress toward the Synthesis of Uncialamycin [PDF]

, 2009
We herein described an intramolecular imino Diels-Alder reaction promoted with BF3.OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quitioline moiety of the uncialamycin, a new enediyne natural ...
Pierre van de Weghe, van de Weghe, Pierre, Desrat, S, Desrat, Sandy, van de Weghe, P, Sandy Desrat   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Huisgen [3 + 2] Dipolar Cycloadditions of Phthalazinium Ylides to Activated Symmetric and Non-Symmetric Alkynes

Molecules, 2020
We present herein a straightforward and efficient pathway for the synthesis of pyrrolophthalazine cycloadducts via Huisgen [3 + 2] dipolar cycloaddition reactions of phthalazinium ylides to methyl propiolate or dimethyl acetylenedicarboxylate (DMAD).
Vasilichia Antoci, Costel Moldoveanu, Ramona Danac, Violeta Mangalagiu, Gheorghita Zbancioc   +4 more
doaj   +1 more source

Design of Amine-Modified Zr–Mg Mixed Oxide Aerogel Nanoarchitectonics with Dual Lewis Acidic and Basic Sites for CO₂/Propylene Oxide Cycloaddition Reactions

Nanomaterials, 2022
The utilization of CO2 attracts much research attention because of global warming. The CO2/epoxide cycloaddition reaction is one technique of CO2 utilization. However, homogeneous catalysts with both Lewis acidic and basic and toxic solvents, such as DMF,
Yi-Feng Lin, Yu-Rou Lai, Hsiang-Ling Sung, Tsair-Wang Chung, Kun-Yi Andrew Lin   +4 more
doaj   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

Molecular Bridges for 2D Nanomaterials

Advanced Functional Materials, EarlyView.
Molecular cross‐linking provides a versatile strategy to engineer interfaces in 2D materials. By tuning the linker backbone, binding mode, and interflake spacing, molecular bridges can regulate charge transport, mechanical integrity, chemical functionality, and processing.
Yudhajit Bhattacharjee, Kevin Synnatschke, Andreas Fery, Hendrik Schlicke   +3 more
wiley   +1 more source

Synthesis of Different Heterocyclic Compounds of Pharmaceutical Relevance [PDF]

This thesis describes the synthesis of different cyclic imines and the exploration of their reactivity with cyclopropenones and 1,3-dipoles,as well as an investigation of the chemistry of the products.
Khan, Musharraf Naveed
core   +2 more sources

Multiplexed Detection of Respiratory Viruses Using Surface Plasmon Resonance Spectroscopy With Ultrathin Carbon Nanomembranes

Advanced Healthcare Materials, EarlyView.
An ultrathin azide‐functionalized carbon nanomembrane (N3‐CNM) provides a versatile biointerface for antibody immobilization on gold SPR sensors. Integrated with a multichannel SPR platform, the functionalized surface enables label‐free, simultaneous detection of SARS‐CoV‐2, Influenza A, and RSV antigens, demonstrating the potential of CNM‐based ...
Ghazaleh Eshaghi, Hamid Reza Rasouli, David Kaiser, Tobias Fischer, Katrin Frankenfeld, Abhishek Sharma, Andrey Turchanin   +6 more
wiley   +1 more source

Oxidation-controlled, Strain-Promoted Tellurophene-Alkyne Cycloaddition (OSTAC): A Bioorthogonal Reaction for Fast and Selective Protein Conjugation [PDF]

, 2022
Noncanonical amino acids (ncAAs) bearing functional groups for bioorthogonal labelling are useful tools for the downstream analysis of nascent polypeptides.
Mark, Nitz, Yong, Jia Bu
core   +2 more sources