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Contemporary synthesis of bioactive cyclobutane natural products

open access: yesGreen Synthesis and Catalysis, 2023
Many cyclobutane natural products have intriguing biological properties that arise from their fascinating chemical structures. Cyclobutane natural products feature a cyclobutane scaffold as the core or as a part of the spirocyclic or fused cyclic core ...
Yusheng Xie, Junyang Liu
exaly   +3 more sources

Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones [PDF]

open access: yesMolecules, 2013
In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with ...
Francesco Secci   +2 more
doaj   +3 more sources

Synthesis of cyclobutane analogues

open access: yesBulletin of the Chemical Society of Ethiopia, 2009
2-(3-Acetyl-2,2-dimethylcyclobutyl)acetic acid (pinonic acid) was synthesized using α-pinene as raw material and potassium permanganate as oxidant. This compound reacted with substituted aniline to produce eight kinds of derivatives with cyclobutane ...
Yan Bai Yin   +4 more
doaj   +2 more sources

Antitumor Profile of Carbon-Bridged Steroids (CBS) and Triterpenoids

open access: yesMarine Drugs, 2021
This review focuses on the rare group of carbon-bridged steroids (CBS) and triterpenoids found in various natural sources such as green, yellow-green, and red algae, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates.
Valery M. Dembitsky   +2 more
doaj   +1 more source

Halogen-bonded co-crystal containing 1,3-diiodoperchlorobenzene and the photoproduct rtct-tetrakis(pyridin-4-yl)cyclobutane resulting in a zigzag topology

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2023
The formation and crystal structure of a zigzag network held together by I...N halogen bonds is reported. In particular, the halogen-bond donor is 1,3-diiodoperchlorobenzene (C6I2Cl4) while the acceptor is the photoproduct rtct-tetrakis(pyridin-4-yl ...
Eric Bosch   +3 more
doaj   +1 more source

The Synthesis of Functionalized Dimethylphosphinoyl Cyclopropanes and Cyclobutanes

open access: yesЖурнал органічної та фармацевтичної хімії, 2023
A simple preparative approach to a series of functionalized dimethylphosphinoyl-containing cyclopropanes and cyclobutanes has been developed; it is based on cyclocondensation of dimethylphosphinoyl acetonitrile with 1,2- and 1,3-dibromoalkanes. Synthetic
Anastasiia M. Aleksandrova   +2 more
doaj   +1 more source

The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

open access: yesЖурнал органічної та фармацевтичної хімії, 2020
Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion.
I. O. Feskov   +5 more
doaj   +1 more source

Halogen-Bond Mediated [2+2] Photodimerizations: À la Carte Access to Unsymmetrical Cyclobutanes in the Solid State

open access: yesMolecules, 2022
The ditopic halogen-bond (X-bond) donors 1,2-, 1,3-, and 1,4-diiodotetrafluorobenzene (1,2-, 1,3-, and 1,4-di-I-tFb, respectively) form binary cocrystals with the unsymmetrical ditopic X-bond acceptor trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene (2,4-bpe ...
Jay Quentin   +2 more
doaj   +1 more source

The Synthesis and Acid-base Properties of α-(Fluoromethyl)- and α-(Difluoromethyl)-substituted Cyclobutane Building Blocks

open access: yesЖурнал органічної та фармацевтичної хімії, 2023
Aim. To synthesize cyclobutane-derived amines and carboxylic acids bearing CH2F or CHF2 groups in the α position; to determine the regularities of the effect of fluoroalkyl substituents on the acid-base properties of the title compounds.
Oleksandr Demchuk, Oleksandr Grygorenko
doaj   +1 more source

Supramolecular Sandwiches: Halogen-Bonded Coformers Direct [2+2] Photoreactivity in Two-Component Cocrystals

open access: yesMolecules, 2020
The halogen-bond (X-bond) donors 1,3- and 1,4-diiodotetrafluorobenzene (1,3-di-I-tFb and 1,4-di-I-tFb, respectively) form cocrystals with trans-1,2-bis(2-pyridyl)ethylene (2,2′-bpe) assembled by N···I X-bonds.
Jay Quentin   +2 more
doaj   +1 more source

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